| pubmed-article:21403132 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21403132 | lifeskim:mentions | umls-concept:C0032098 | lld:lifeskim |
| pubmed-article:21403132 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:21403132 | lifeskim:mentions | umls-concept:C1167160 | lld:lifeskim |
| pubmed-article:21403132 | lifeskim:mentions | umls-concept:C1155265 | lld:lifeskim |
| pubmed-article:21403132 | lifeskim:mentions | umls-concept:C1413614 | lld:lifeskim |
| pubmed-article:21403132 | lifeskim:mentions | umls-concept:C1428371 | lld:lifeskim |
| pubmed-article:21403132 | lifeskim:mentions | umls-concept:C1154971 | lld:lifeskim |
| pubmed-article:21403132 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:21403132 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:21403132 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:21403132 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:21403132 | pubmed:dateCreated | 2011-5-6 | lld:pubmed |
| pubmed-article:21403132 | pubmed:abstractText | COP9 plays a role in plant innate immunity. The role of COP9 in mammalian innate immune responses is unknown. Here, we show that the COP9 signalosome subunit 5 (CSN5) is required for activation of proinflammatory kinases p38 and Erk and for down-regulation of the expression of genes regulated by nuclear factor E2-related factor 2. Mice with myeloid-specific CSN5 deficiency have lower mortality in polymicrobial sepsis. CSN5 is required for both Toll-like receptor (TLR) and reactive oxygen species-mediated deneddylation of Cul3, which is essential for Cul3/Keap1-mediated degradation of nuclear factor E2-related factor 2. On the basis of our results COP9 subunit CSN5 is considered to be an essential component of mammalian innate immunity. | lld:pubmed |
| pubmed-article:21403132 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21403132 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21403132 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:21403132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21403132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21403132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21403132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21403132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21403132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21403132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21403132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21403132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21403132 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21403132 | pubmed:month | May | lld:pubmed |
| pubmed-article:21403132 | pubmed:issn | 1528-0020 | lld:pubmed |
| pubmed-article:21403132 | pubmed:author | pubmed-author:ZhangHuang-Ge... | lld:pubmed |
| pubmed-article:21403132 | pubmed:author | pubmed-author:MillerDonaldD | lld:pubmed |
| pubmed-article:21403132 | pubmed:author | pubmed-author:CheadleWillia... | lld:pubmed |
| pubmed-article:21403132 | pubmed:author | pubmed-author:GrizzleWillia... | lld:pubmed |
| pubmed-article:21403132 | pubmed:author | pubmed-author:PardiRuggeroR | lld:pubmed |
| pubmed-article:21403132 | pubmed:author | pubmed-author:XiangXiaoyuX | lld:pubmed |
| pubmed-article:21403132 | pubmed:author | pubmed-author:ZhangShuangyi... | lld:pubmed |
| pubmed-article:21403132 | pubmed:author | pubmed-author:ShahSpandan... | lld:pubmed |
| pubmed-article:21403132 | pubmed:author | pubmed-author:DengZhongbinZ | lld:pubmed |
| pubmed-article:21403132 | pubmed:author | pubmed-author:MountzJohnJ | lld:pubmed |
| pubmed-article:21403132 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21403132 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:21403132 | pubmed:volume | 117 | lld:pubmed |
| pubmed-article:21403132 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21403132 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21403132 | pubmed:pagination | 4796-804 | lld:pubmed |
| pubmed-article:21403132 | pubmed:meshHeading | pubmed-meshheading:21403132... | lld:pubmed |
| pubmed-article:21403132 | pubmed:meshHeading | pubmed-meshheading:21403132... | lld:pubmed |
| pubmed-article:21403132 | pubmed:meshHeading | pubmed-meshheading:21403132... | lld:pubmed |
| pubmed-article:21403132 | pubmed:meshHeading | pubmed-meshheading:21403132... | lld:pubmed |
| pubmed-article:21403132 | pubmed:meshHeading | pubmed-meshheading:21403132... | lld:pubmed |
| pubmed-article:21403132 | pubmed:meshHeading | pubmed-meshheading:21403132... | lld:pubmed |
| pubmed-article:21403132 | pubmed:meshHeading | pubmed-meshheading:21403132... | lld:pubmed |
| pubmed-article:21403132 | pubmed:meshHeading | pubmed-meshheading:21403132... | lld:pubmed |
| pubmed-article:21403132 | pubmed:meshHeading | pubmed-meshheading:21403132... | lld:pubmed |
| pubmed-article:21403132 | pubmed:meshHeading | pubmed-meshheading:21403132... | lld:pubmed |
| pubmed-article:21403132 | pubmed:meshHeading | pubmed-meshheading:21403132... | lld:pubmed |
| pubmed-article:21403132 | pubmed:meshHeading | pubmed-meshheading:21403132... | lld:pubmed |
| pubmed-article:21403132 | pubmed:meshHeading | pubmed-meshheading:21403132... | lld:pubmed |
| pubmed-article:21403132 | pubmed:meshHeading | pubmed-meshheading:21403132... | lld:pubmed |
| pubmed-article:21403132 | pubmed:meshHeading | pubmed-meshheading:21403132... | lld:pubmed |
| pubmed-article:21403132 | pubmed:meshHeading | pubmed-meshheading:21403132... | lld:pubmed |
| pubmed-article:21403132 | pubmed:meshHeading | pubmed-meshheading:21403132... | lld:pubmed |
| pubmed-article:21403132 | pubmed:meshHeading | pubmed-meshheading:21403132... | lld:pubmed |
| pubmed-article:21403132 | pubmed:meshHeading | pubmed-meshheading:21403132... | lld:pubmed |
| pubmed-article:21403132 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21403132 | pubmed:articleTitle | Plant homologue constitutive photomorphogenesis 9 (COP9) signalosome subunit CSN5 regulates innate immune responses in macrophages. | lld:pubmed |
| pubmed-article:21403132 | pubmed:affiliation | Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA. | lld:pubmed |
| pubmed-article:21403132 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21403132 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:21403132 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:26754 | entrezgene:pubmed | pubmed-article:21403132 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21403132 | lld:entrezgene |
