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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2011-5-6
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pubmed:abstractText |
COP9 plays a role in plant innate immunity. The role of COP9 in mammalian innate immune responses is unknown. Here, we show that the COP9 signalosome subunit 5 (CSN5) is required for activation of proinflammatory kinases p38 and Erk and for down-regulation of the expression of genes regulated by nuclear factor E2-related factor 2. Mice with myeloid-specific CSN5 deficiency have lower mortality in polymicrobial sepsis. CSN5 is required for both Toll-like receptor (TLR) and reactive oxygen species-mediated deneddylation of Cul3, which is essential for Cul3/Keap1-mediated degradation of nuclear factor E2-related factor 2. On the basis of our results COP9 subunit CSN5 is considered to be an essential component of mammalian innate immunity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Cops5 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cul3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cullin Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/NF-E2-Related Factor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Nfe2l2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Hydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptors
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1528-0020
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
5
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pubmed:volume |
117
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4796-804
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pubmed:meshHeading |
pubmed-meshheading:21403132-Animals,
pubmed-meshheading:21403132-Antioxidants,
pubmed-meshheading:21403132-Cullin Proteins,
pubmed-meshheading:21403132-Female,
pubmed-meshheading:21403132-Immunity, Innate,
pubmed-meshheading:21403132-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:21403132-Lung,
pubmed-meshheading:21403132-MAP Kinase Signaling System,
pubmed-meshheading:21403132-Macrophage Activation,
pubmed-meshheading:21403132-Macrophages,
pubmed-meshheading:21403132-Male,
pubmed-meshheading:21403132-Mice,
pubmed-meshheading:21403132-Mice, Knockout,
pubmed-meshheading:21403132-NF-E2-Related Factor 2,
pubmed-meshheading:21403132-Peptide Hydrolases,
pubmed-meshheading:21403132-Shock, Septic,
pubmed-meshheading:21403132-Signal Transduction,
pubmed-meshheading:21403132-Toll-Like Receptors,
pubmed-meshheading:21403132-Up-Regulation
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pubmed:year |
2011
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pubmed:articleTitle |
Plant homologue constitutive photomorphogenesis 9 (COP9) signalosome subunit CSN5 regulates innate immune responses in macrophages.
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pubmed:affiliation |
Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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