Linked Life Data

21399802

Source:http://linkedlifedata.com/resource/pubmed/id/21399802

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
17
pubmed:dateCreated
2011-4-20
pubmed:abstractText
The I(2)-adducts of drugs propylthiouracil (PTU) and methimazole (MeImSH) oxidize liquid mercury in dichloromethane to separate in good yield the neutral complexes [HgI(2)(PTU)(2)·MeOH] (1), [HgI(2)(PTU)(2)·HgI(2)] (2), and [Hg(2)I(4)(MeImSH)(2)] (3). The single crystal X-ray diffraction analysis of 1-2 shows that the Hg(II) center is coordinated by two sulfur atoms and by two iodine atoms in a tetrahedral geometry. In complex 2 almost linear molecules of HgI(2) result encapsulated in the crystal packing enfolded by the hydrophobic propyl appendages of coordinated units of PTU. X-ray analysis of complex 3 shows the presence of dimeric [Hg(2)I(4)(MeImSH)(2)] molecules to form Hg(2)S(2)I(4) cores. The intra- and intermolecular hydrogen bonds concerning PTU and MeImSH have been evaluated. The oxidation of Hg(0) to Hg(II) requires a two-electron transfer process accomplished by an oxidative addition from the "activated" iodine moiety. The oxidizing and complexing properties of PTU-I(2) and MeImSH-I(2) have been interpreted considering the S-donor to I(2) interaction that leads to a charge separation between the sulfur-bound iodine atom S-I and the terminal I atom. Compounds 1, 2, and 3 react with tetraethylammonium iodide to separate the compound (Et(4)N)(2)[HgI(4)] with the release of free PTU and MeImSH, respectively. The reported dissolution technique could be applied to the recovery of mercury from waste electrical and electronic equipment (WEEE) scrap, the nature of complexes 1-3 makes it possible the easy separation of the mercury as tetraiodomercurate anion and the recycling of the donors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1477-9234
pubmed:author
pubmed:issnType
Electronic
pubmed:day
7
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4505-13
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Oxidative properties of iodine-adducts of propylthiouracil and methimazole: direct synthesis of mercury(II) complexes from the reaction with liquid mercury.
pubmed:affiliation
Università degli Studi di Cagliari, Dipartimento di Chimica Inorganica ed Analitica, Cittadella Universitaria, Monserrato (CA), Italy. isaia@unica.it
pubmed:publicationType
Journal Article