Linked Life Data

2138619

Source:http://linkedlifedata.com/resource/pubmed/id/2138619

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1990-5-10
pubmed:databankReference
pubmed:abstractText
The high affinity IgE receptor, Fc epsilon RI, is one of the key molecules involved in allergic reactions. It is a tetrameric complex (alpha beta gamma 2). The gamma chains from Fc epsilon RI are also subunits of other Fc receptors. We have isolated, characterized, and sequenced the gene for the human gamma chain of Fc epsilon RI. It consists of five exons and spans 4 kilobases. The leader sequence is encoded by two exons, the second of which also contains the short extracellular domain, the hydrophobic transmembrane region, and the beginning of the cytoplasmic tail. Three short exons encode the remaining of the polypeptide and the 3'-untranslated flanking sequence. The transcription initiation sites have been mapped. Comparison between the gene structures of the gamma chain of the Fc receptor and of the zeta chain of the T-cell receptor indicates that these genes have evolved from a common ancestor by duplication and that they define a new gene family. In addition to being localized on the same chromosome, both genes show an analogous organization of their exons. A high level of homology is found in three of their respective exons, and the splice sites between them are identical. Furthermore, gamma and zeta chains are essential for surface expression of their respective receptors. Therefore, gamma chains of Fc receptors and zeta chains of T-cell receptors may also define a new family of functionally related polypeptides. Expression studies in COS cells show that the human gamma chain alone is sufficient to achieve expression of the human alpha chain on the cell surface, whereas both beta and gamma chains are required for the surface expression of the rodent alpha chain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
265
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6448-52
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:2138619-Amino Acid Sequence, pubmed-meshheading:2138619-Antigens, CD, pubmed-meshheading:2138619-Antigens, Differentiation, pubmed-meshheading:2138619-Antigens, Differentiation, B-Lymphocyte, pubmed-meshheading:2138619-Base Sequence, pubmed-meshheading:2138619-Basophils, pubmed-meshheading:2138619-Cloning, Molecular, pubmed-meshheading:2138619-Gene Expression, pubmed-meshheading:2138619-Gene Library, pubmed-meshheading:2138619-Genomic Library, pubmed-meshheading:2138619-Humans, pubmed-meshheading:2138619-Macromolecular Substances, pubmed-meshheading:2138619-Molecular Sequence Data, pubmed-meshheading:2138619-Multigene Family, pubmed-meshheading:2138619-Nucleic Acid Hybridization, pubmed-meshheading:2138619-Receptors, Antigen, T-Cell, pubmed-meshheading:2138619-Receptors, Fc, pubmed-meshheading:2138619-Receptors, IgE, pubmed-meshheading:2138619-Receptors, IgG, pubmed-meshheading:2138619-Restriction Mapping, pubmed-meshheading:2138619-Transcription, Genetic
pubmed:year
1990
pubmed:articleTitle
Characterization and expression of the gene for the human Fc receptor gamma subunit. Definition of a new gene family.
pubmed:affiliation
Arthritis and Rheumatism Branch, National Institute of Arthritis, Musculoskeletal, and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892.
pubmed:publicationType
Journal Article, Comparative Study