| pubmed-article:21383057 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21383057 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:21383057 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:21383057 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:21383057 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:21383057 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:21383057 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:21383057 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:21383057 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:21383057 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:21383057 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:21383057 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:21383057 | lifeskim:mentions | umls-concept:C1883220 | lld:lifeskim |
| pubmed-article:21383057 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:21383057 | pubmed:dateCreated | 2011-3-15 | lld:pubmed |
| pubmed-article:21383057 | pubmed:abstractText | The immunoglobulin (Ig) superfamily consists of many critical immune regulators, including the B7 family ligands and receptors. In this study, we identify a novel and structurally distinct Ig superfamily inhibitory ligand, whose extracellular domain bears homology to the B7 family ligand PD-L1. This molecule is designated V-domain Ig suppressor of T cell activation (VISTA). VISTA is primarily expressed on hematopoietic cells, and VISTA expression is highly regulated on myeloid antigen-presenting cells (APCs) and T cells. A soluble VISTA-Ig fusion protein or VISTA expression on APCs inhibits T cell proliferation and cytokine production in vitro. A VISTA-specific monoclonal antibody interferes with VISTA-induced suppression of T cell responses by VISTA-expressing APCs in vitro. Furthermore, anti-VISTA treatment exacerbates the development of the T cell-mediated autoimmune disease experimental autoimmune encephalomyelitis in mice. Finally, VISTA overexpression on tumor cells interferes with protective antitumor immunity in vivo in mice. These findings show that VISTA, a novel immunoregulatory molecule, has functional activities that are nonredundant with other Ig superfamily members and may play a role in the development of autoimmunity and immune surveillance in cancer. | lld:pubmed |
| pubmed-article:21383057 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21383057 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21383057 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21383057 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21383057 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21383057 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21383057 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21383057 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21383057 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21383057 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21383057 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21383057 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21383057 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:21383057 | pubmed:issn | 1540-9538 | lld:pubmed |
| pubmed-article:21383057 | pubmed:author | pubmed-author:UrenCC | lld:pubmed |
| pubmed-article:21383057 | pubmed:author | pubmed-author:NoelleRandolp... | lld:pubmed |
| pubmed-article:21383057 | pubmed:author | pubmed-author:WangLiL | lld:pubmed |
| pubmed-article:21383057 | pubmed:author | pubmed-author:AhonenCoryC | lld:pubmed |
| pubmed-article:21383057 | pubmed:author | pubmed-author:FavaRoy ARA | lld:pubmed |
| pubmed-article:21383057 | pubmed:author | pubmed-author:FiserAndrasA | lld:pubmed |
| pubmed-article:21383057 | pubmed:author | pubmed-author:LuLi-FanLF | lld:pubmed |
| pubmed-article:21383057 | pubmed:author | pubmed-author:GondekDavidD | lld:pubmed |
| pubmed-article:21383057 | pubmed:author | pubmed-author:GuoYanxiaY | lld:pubmed |
| pubmed-article:21383057 | pubmed:author | pubmed-author:AlmoSteveS | lld:pubmed |
| pubmed-article:21383057 | pubmed:author | pubmed-author:WasiukAnnaA | lld:pubmed |
| pubmed-article:21383057 | pubmed:author | pubmed-author:RubinsteinRot... | lld:pubmed |
| pubmed-article:21383057 | pubmed:author | pubmed-author:LinesJanet... | lld:pubmed |
| pubmed-article:21383057 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21383057 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:21383057 | pubmed:volume | 208 | lld:pubmed |
| pubmed-article:21383057 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21383057 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21383057 | pubmed:pagination | 577-92 | lld:pubmed |
| pubmed-article:21383057 | pubmed:dateRevised | 2011-9-15 | lld:pubmed |
| pubmed-article:21383057 | pubmed:meshHeading | pubmed-meshheading:21383057... | lld:pubmed |
| pubmed-article:21383057 | pubmed:meshHeading | pubmed-meshheading:21383057... | lld:pubmed |
| pubmed-article:21383057 | pubmed:meshHeading | pubmed-meshheading:21383057... | lld:pubmed |
| pubmed-article:21383057 | pubmed:meshHeading | pubmed-meshheading:21383057... | lld:pubmed |
| pubmed-article:21383057 | pubmed:meshHeading | pubmed-meshheading:21383057... | lld:pubmed |
| pubmed-article:21383057 | pubmed:meshHeading | pubmed-meshheading:21383057... | lld:pubmed |
| pubmed-article:21383057 | pubmed:meshHeading | pubmed-meshheading:21383057... | lld:pubmed |
| pubmed-article:21383057 | pubmed:meshHeading | pubmed-meshheading:21383057... | lld:pubmed |
| pubmed-article:21383057 | pubmed:meshHeading | pubmed-meshheading:21383057... | lld:pubmed |
| pubmed-article:21383057 | pubmed:meshHeading | pubmed-meshheading:21383057... | lld:pubmed |
| pubmed-article:21383057 | pubmed:meshHeading | pubmed-meshheading:21383057... | lld:pubmed |
| pubmed-article:21383057 | pubmed:meshHeading | pubmed-meshheading:21383057... | lld:pubmed |
| pubmed-article:21383057 | pubmed:meshHeading | pubmed-meshheading:21383057... | lld:pubmed |
| pubmed-article:21383057 | pubmed:meshHeading | pubmed-meshheading:21383057... | lld:pubmed |
| pubmed-article:21383057 | pubmed:meshHeading | pubmed-meshheading:21383057... | lld:pubmed |
| pubmed-article:21383057 | pubmed:meshHeading | pubmed-meshheading:21383057... | lld:pubmed |
| pubmed-article:21383057 | pubmed:meshHeading | pubmed-meshheading:21383057... | lld:pubmed |
| pubmed-article:21383057 | pubmed:meshHeading | pubmed-meshheading:21383057... | lld:pubmed |
| pubmed-article:21383057 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21383057 | pubmed:articleTitle | VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses. | lld:pubmed |
| pubmed-article:21383057 | pubmed:affiliation | Department of Microbiology and Immunology, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03766, USA. | lld:pubmed |
| pubmed-article:21383057 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21383057 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:18566 | entrezgene:pubmed | pubmed-article:21383057 | lld:entrezgene |
| entrez-gene:20371 | entrezgene:pubmed | pubmed-article:21383057 | lld:entrezgene |
| entrez-gene:74048 | entrezgene:pubmed | pubmed-article:21383057 | lld:entrezgene |
