Source:http://linkedlifedata.com/resource/pubmed/id/21383057
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2011-3-15
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| pubmed:abstractText |
The immunoglobulin (Ig) superfamily consists of many critical immune regulators, including the B7 family ligands and receptors. In this study, we identify a novel and structurally distinct Ig superfamily inhibitory ligand, whose extracellular domain bears homology to the B7 family ligand PD-L1. This molecule is designated V-domain Ig suppressor of T cell activation (VISTA). VISTA is primarily expressed on hematopoietic cells, and VISTA expression is highly regulated on myeloid antigen-presenting cells (APCs) and T cells. A soluble VISTA-Ig fusion protein or VISTA expression on APCs inhibits T cell proliferation and cytokine production in vitro. A VISTA-specific monoclonal antibody interferes with VISTA-induced suppression of T cell responses by VISTA-expressing APCs in vitro. Furthermore, anti-VISTA treatment exacerbates the development of the T cell-mediated autoimmune disease experimental autoimmune encephalomyelitis in mice. Finally, VISTA overexpression on tumor cells interferes with protective antitumor immunity in vivo in mice. These findings show that VISTA, a novel immunoregulatory molecule, has functional activities that are nonredundant with other Ig superfamily members and may play a role in the development of autoimmunity and immune surveillance in cancer.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
1540-9538
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| pubmed:author |
pubmed-author:AhonenCoryC,
pubmed-author:AlmoSteveS,
pubmed-author:FavaRoy ARA,
pubmed-author:FiserAndrasA,
pubmed-author:GondekDavidD,
pubmed-author:GuoYanxiaY,
pubmed-author:LinesJanet LJL,
pubmed-author:LuLi-FanLF,
pubmed-author:NoelleRandolph JRJ,
pubmed-author:RubinsteinRotemR,
pubmed-author:UrenCC,
pubmed-author:WangLiL,
pubmed-author:WasiukAnnaA
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| pubmed:issnType |
Electronic
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| pubmed:day |
14
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| pubmed:volume |
208
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
577-92
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| pubmed:dateRevised |
2011-9-15
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| pubmed:meshHeading |
pubmed-meshheading:21383057-Animals,
pubmed-meshheading:21383057-Antibodies, Monoclonal,
pubmed-meshheading:21383057-Antigen-Presenting Cells,
pubmed-meshheading:21383057-Antigens, CD80,
pubmed-meshheading:21383057-CD4-Positive T-Lymphocytes,
pubmed-meshheading:21383057-CD8-Positive T-Lymphocytes,
pubmed-meshheading:21383057-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:21383057-Flow Cytometry,
pubmed-meshheading:21383057-Gene Expression Regulation,
pubmed-meshheading:21383057-Immunoglobulins,
pubmed-meshheading:21383057-Ligands,
pubmed-meshheading:21383057-Lymphocyte Activation,
pubmed-meshheading:21383057-Mice,
pubmed-meshheading:21383057-Mice, Inbred C57BL,
pubmed-meshheading:21383057-Mice, Transgenic,
pubmed-meshheading:21383057-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21383057-T-Lymphocytes,
pubmed-meshheading:21383057-Tumor Cells, Cultured
|
| pubmed:year |
2011
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| pubmed:articleTitle |
VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses.
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| pubmed:affiliation |
Department of Microbiology and Immunology, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03766, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|