Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-3-22
pubmed:abstractText
We have studied the mechanism of generation of insulin mediators by using specific antibodies raised against the oligosaccharide anchor of membrane proteins. These antibodies (i) block the in vitro effects of purified insulin mediators and (ii) block the insulin-induced stimulation of pyruvate dehydrogenase in intact BC3H1 myocytes but not insulin-stimulated glucose uptake, generation of diacylglycerol, or generation of insulin mediators. When added to intact cells in the presence of insulin, these antibodies induce the accumulation of insulin mediator activity in the extracellular medium. We therefore conclude that these anti-inositolglycan antibodies block some of the effects of insulin by inhibiting the uptake of specific insulin mediators generated outside the cell.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-10986, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-205248, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-2530916, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-2833261, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-2843987, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-2848807, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-2865681, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-2897081, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-2897365, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-2951371, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-2985364, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-3016721, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-3016898, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-3030696, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-3042371, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-3047589, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-3076102, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-3087735, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-3158511, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-3282305, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-3288199, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-3288620, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-3293531, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-3311849, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-3322285, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-3340856, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-3546286, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-3759991, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-3858818, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-3917578, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-4055788, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-6188057, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-6196605, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-6304042, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-6311211, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-6757016, http://linkedlifedata.com/resource/pubmed/commentcorrection/2137614-913568
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1476-80
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:2137614-Animals, pubmed-meshheading:2137614-Antibodies, Protozoan, pubmed-meshheading:2137614-Antigen-Antibody Complex, pubmed-meshheading:2137614-Cells, Cultured, pubmed-meshheading:2137614-Chromatography, Affinity, pubmed-meshheading:2137614-Diglycerides, pubmed-meshheading:2137614-Glycolipids, pubmed-meshheading:2137614-Glycosylphosphatidylinositols, pubmed-meshheading:2137614-Insulin, pubmed-meshheading:2137614-Kinetics, pubmed-meshheading:2137614-Mice, pubmed-meshheading:2137614-Mice, Inbred C3H, pubmed-meshheading:2137614-Muscles, pubmed-meshheading:2137614-Myristic Acid, pubmed-meshheading:2137614-Myristic Acids, pubmed-meshheading:2137614-Phosphatidylinositols, pubmed-meshheading:2137614-Pyruvate Dehydrogenase Complex, pubmed-meshheading:2137614-Trypanosoma brucei brucei, pubmed-meshheading:2137614-Variant Surface Glycoproteins, Trypanosoma
pubmed:year
1990
pubmed:articleTitle
Anti-inositolglycan antibodies selectively block some of the actions of insulin in intact BC3H1 cells.
pubmed:affiliation
Department of Pharmacology, University of Virginia, Charlottesville 22908.
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