Linked Life Data

2137574

Source:http://linkedlifedata.com/resource/pubmed/id/2137574

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3 Pt 1
pubmed:dateCreated
1990-3-20
pubmed:abstractText
Based on an increased turnover of the hemostatic system, it is believed that pregnancy is associated with "hypercoagulability." However, this hypothesis is based primarily on the measurement of specific coagulation factors or functional tests reflecting hemostatic activity in vitro. Using recent technological advances, we determined the effect of pregnancy on hemostasis in vivo by measuring 11 specific hemostatic indices simultaneously in 28 healthy pregnant women and in 24 nonpregnant female controls. Significant increases were found in fibrinopeptide A (P less than .01), beta thromboglobulin (P less than .001), platelet factor 4 (P less than .02), and fibrin(ogen) degradation products (P less than .001), suggesting increased platelet turnover, clotting, and fibrinolysis. This state of compensated, accelerated intravascular coagulation may be necessary for maintenance of the uterine-placental interface and preparation for the hemostatic challenge of delivery.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0029-7844
pubmed:author
pubmed:issnType
Print
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
385-9
pubmed:dateRevised
2009-10-26
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Increased intravascular coagulation associated with pregnancy.
pubmed:affiliation
Department of Anesthesiology, Wayne State University, Hutzel Hospital, Detroit, Michigan.
pubmed:publicationType
Journal Article