Linked Life Data

2136864

Source:http://linkedlifedata.com/resource/pubmed/id/2136864

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-2-14
pubmed:abstractText
A decrease in the myocardial level of the mRNA encoding the Ca2(+)-ATPase of the sarcoplasmic reticulum (SR) has been recently reported during experimental cardiac hypertrophy and failure. To determine if such a deficit occurs in human end-stage heart failure, we compared the SR Ca2(+)-ATPase mRNA levels in left (LV) and right ventricular (RV) specimens from 13 patients undergoing cardiac transplantation (6 idiopathic dilated cardiomyopathies; 4 coronary artery diseases with myocardial infarctions; 3 diverse etiologies) with control heart samples using a rat cardiac SR Ca2(+)-ATPase cDNA probe. We observed a marked decrease in the mRNA for the Ca2(+)-ATPase relative to both the 18S ribosomal RNA and the myosin heavy chain mRNA in LV specimens of patients with heart failure compared to controls (-48%, P less than 0.01 and -47%, P less than 0.05, respectively). The LV ratio of Ca2(+)-ATPase mRNA to 18S RNA positively correlated with cardiac index (P less than 0.02). The RV ratio correlated negatively with systolic, diastolic and mean pulmonary arterial pressures (P less than 0.02, P less than 0.02, and P less than 0.01, respectively). We suggest that a decrease of the SR Ca2(+)-ATPase mRNA in the myocardium plays an important role in alterations of Ca2+ movements and myocardial relaxation reported during human end-stage heart failure.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2136864-205659, http://linkedlifedata.com/resource/pubmed/commentcorrection/2136864-2441994, http://linkedlifedata.com/resource/pubmed/commentcorrection/2136864-2522936, http://linkedlifedata.com/resource/pubmed/commentcorrection/2136864-2523077, http://linkedlifedata.com/resource/pubmed/commentcorrection/2136864-2529132, http://linkedlifedata.com/resource/pubmed/commentcorrection/2136864-2542094, http://linkedlifedata.com/resource/pubmed/commentcorrection/2136864-2831089, http://linkedlifedata.com/resource/pubmed/commentcorrection/2136864-2844796, http://linkedlifedata.com/resource/pubmed/commentcorrection/2136864-2844797, http://linkedlifedata.com/resource/pubmed/commentcorrection/2136864-2933178, http://linkedlifedata.com/resource/pubmed/commentcorrection/2136864-2936465, http://linkedlifedata.com/resource/pubmed/commentcorrection/2136864-2962507, http://linkedlifedata.com/resource/pubmed/commentcorrection/2136864-2965149, http://linkedlifedata.com/resource/pubmed/commentcorrection/2136864-2969307, http://linkedlifedata.com/resource/pubmed/commentcorrection/2136864-3608112, http://linkedlifedata.com/resource/pubmed/commentcorrection/2136864-4837895, http://linkedlifedata.com/resource/pubmed/commentcorrection/2136864-518835, http://linkedlifedata.com/resource/pubmed/commentcorrection/2136864-5364651, http://linkedlifedata.com/resource/pubmed/commentcorrection/2136864-6235737, http://linkedlifedata.com/resource/pubmed/commentcorrection/2136864-7045682
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
85
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
305-9
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Altered sarcoplasmic reticulum Ca2(+)-ATPase gene expression in the human ventricle during end-stage heart failure.
pubmed:affiliation
Institut National de la Santé et de la Recherche Medicale Unité 127, Hôpital Lariboisière, Paris, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't