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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2011-3-15
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pubmed:abstractText |
Cardiac hypertrophy involves growth responses to a variety of stimuli triggered by increased workload. It is an independent risk factor for heart failure and sudden death. Mammalian target of rapamycin (mTOR) plays a key role in cellular growth responses by integrating growth factor and energy status signals. It is found in 2 structurally and functionally distinct multiprotein complexes called mTOR complex (mTORC) 1 and mTORC2. The role of each of these branches of mTOR signaling in the adult heart is currently unknown.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Atrial Natriuretic Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Eif4ebp1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Myosin Heavy Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Natriuretic Peptide, Brain,
http://linkedlifedata.com/resource/pubmed/chemical/Nonmuscle Myosin Type IIB,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ribosomal Protein S6 Kinases, 90-kDa,
http://linkedlifedata.com/resource/pubmed/chemical/Rps6ka1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/nonmuscle myosin type IIB heavy...,
http://linkedlifedata.com/resource/pubmed/chemical/raptor protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:BerthonnecheCorinneC,
pubmed-author:BrinkMarijkeM,
pubmed-author:HallMichael NMN,
pubmed-author:KrishnanJayaJ,
pubmed-author:LerchRenéR,
pubmed-author:MorandiChristianC,
pubmed-author:PedrazziniThierryT,
pubmed-author:PellieuxCorinneC,
pubmed-author:PlaisanceIsabelleI,
pubmed-author:RüeggMarkus AMA,
pubmed-author:ShendePankajP,
pubmed-author:ZorzatoFrancescoF
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
123
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1073-82
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pubmed:meshHeading |
pubmed-meshheading:21357822-Animals,
pubmed-meshheading:21357822-Apoptosis,
pubmed-meshheading:21357822-Atrial Natriuretic Factor,
pubmed-meshheading:21357822-Autophagy,
pubmed-meshheading:21357822-Cardiomegaly,
pubmed-meshheading:21357822-Carrier Proteins,
pubmed-meshheading:21357822-Energy Metabolism,
pubmed-meshheading:21357822-Gene Expression,
pubmed-meshheading:21357822-Heart Failure,
pubmed-meshheading:21357822-Heart Rate,
pubmed-meshheading:21357822-Male,
pubmed-meshheading:21357822-Mice,
pubmed-meshheading:21357822-Mice, Inbred C57BL,
pubmed-meshheading:21357822-Mice, Knockout,
pubmed-meshheading:21357822-Mitochondria, Heart,
pubmed-meshheading:21357822-Myosin Heavy Chains,
pubmed-meshheading:21357822-Natriuretic Peptide, Brain,
pubmed-meshheading:21357822-Nonmuscle Myosin Type IIB,
pubmed-meshheading:21357822-Phosphoproteins,
pubmed-meshheading:21357822-Phosphorylation,
pubmed-meshheading:21357822-Ribosomal Protein S6 Kinases, 90-kDa
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pubmed:year |
2011
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pubmed:articleTitle |
Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice.
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pubmed:affiliation |
Department of Biomedicine, University of Basel and University Hospital Basel, Hebelstrasse 20, CH-4031 Basel, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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