Linked Life Data

21354859

Source:http://linkedlifedata.com/resource/pubmed/id/21354859

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2011-4-4
pubmed:abstractText
Expression of the pre-T cell receptor (pTCR) by immature thymocytes is crucial for T cell development. The pTCR comprises an invariant pre-T? chain that pairs with a newly rearranged TCR? chain and CD3 signaling components. Despite its similarity to the mature ??TCR, which binds to specific peptide-loaded major histocompatibility molecules, the pTCR functions in a ligand-independent manner. Precisely how pTCR functions autonomously has remained a source of intense debate. Recently, the structure of the extracellular domain of the pTCR has been determined, providing insight into the mechanism of pTCR autonomous signaling. In this review, we reflect on the current understanding of pTCR function and draw comparisons to the mechanisms employed by the mature ??TCR and the related pre-B cell receptor.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1471-4981
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
165-70
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Insight into the basis of autonomous immunoreceptor activation.
pubmed:affiliation
The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't