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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1979-1-15
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pubmed:abstractText |
Cyclic AMP is required for optimal synthesis of D-serine deaminase synthesis from dsdO+ templates and for optimal hyperinducible synthesis from low constitutive dsdO templates both in vitro and in vivo. Neither D-serine, cyclic AMP, nor dsdC activator has an effect on expression of a high constitutive dsdO template. The synthesis of the dsdC activator itself in vitro is independent of cyclic AMP. Guanosine tetraphosphate does not have a significant effect on in vitro D-serine deaminase synthesis from dsdO+ or dsdO templates. A previously described class of dsdO mutants showing partial catabolite sensitivity of constitutive D-serine deaminase synthesis proved to be low dsdO types. They all contain a low constitutive dsdC mutation; the two effects are additive with regard to level of constitutivity, but only that portion of synthesis attributable to the dsdC mutation is cyclic AMP dependent.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/213417-1090588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/213417-1090589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/213417-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/213417-163811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/213417-190211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/213417-213419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/213417-347444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/213417-4149344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/213417-4347927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/213417-4359331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/213417-4363749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/213417-4587256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/213417-4593305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/213417-4605337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/213417-5340178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/213417-783126
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0021-9193
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
136
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
104-10
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:213417-Bacterial Proteins,
pubmed-meshheading:213417-Cyclic AMP,
pubmed-meshheading:213417-Enzyme Induction,
pubmed-meshheading:213417-Escherichia coli,
pubmed-meshheading:213417-Guanine Nucleotides,
pubmed-meshheading:213417-Guanosine Tetraphosphate,
pubmed-meshheading:213417-L-Serine Dehydratase,
pubmed-meshheading:213417-Models, Biological,
pubmed-meshheading:213417-Mutation,
pubmed-meshheading:213417-Serine
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pubmed:year |
1978
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pubmed:articleTitle |
Role of small molecules in regulation of D-serine deaminase synthesis.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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