Linked Life Data

2134014

Source:http://linkedlifedata.com/resource/pubmed/id/2134014

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1992-4-15
pubmed:abstractText
The identification and sequencing of the antigen receptor of T cells coupled with the demonstration that MHC proteins specifically bind immunogenic peptides, and the solution of the crystal structure of HLA A2 and Aw68 collectively have led to a working model of how T cells recognize protein antigens. In contrast with many other known receptor-ligand interactions, this unique recognition mechanism has evolved to allow receptors on two separate cells to contact a common peptide ligand. To accomplish this, MHC proteins and the T cell receptor both differ from previously defined biological receptors in many respects. The MHC class I and II molecules are membrane glycoproteins that have evolved the remarkable capacity to bind and display on the surface of cells an extremely large number of structurally diverse peptides, while the antigen specific receptors of T cells are positively selected to specifically interact with the MHC protein alleles of the individual and only some of the repertoire of self peptides.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1044-5323
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
283-95
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
The ternary complex: T cell receptor, MHC protein, and immunogenic peptide.
pubmed:affiliation
ImmuLogic Pharmaceutical Corporation, Palo Alto, CA 94304.
pubmed:publicationType
Journal Article, Review