| pubmed-article:21329689 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21329689 | lifeskim:mentions | umls-concept:C1843926 | lld:lifeskim |
| pubmed-article:21329689 | lifeskim:mentions | umls-concept:C1411976 | lld:lifeskim |
| pubmed-article:21329689 | lifeskim:mentions | umls-concept:C1155266 | lld:lifeskim |
| pubmed-article:21329689 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:21329689 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:21329689 | pubmed:dateCreated | 2011-3-15 | lld:pubmed |
| pubmed-article:21329689 | pubmed:abstractText | Atherosclerosis is an inflammatory process due to oxidized low-density lipoprotein (oxLDL) accumulation in macrophages. We investigated the involvement of microRNAs in oxLDL accumulation and inflammatory response in macrophages. The expression of miR-146a decreases under oxLDL stimulation. MiR-146a significantly reduces intracellular LDL cholesterol content and secretion of interleukin 6, interleukin 8, chemokine (C-C motif) ligand 2 and matrix metallopeptidase 9. Toll-like receptor 4 (TLR4) is a relevant target of miR-146a, and miR-146a inhibits the activation of TLR4-dependent intracellular signaling pathways involved in cytoskeleton rearrangement, lipid uptake, and inflammatory cytokine secretion. These results indicate that miR-146a contributes to the regulation of both oxLDL accumulation and inflammatory response by negatively regulating TLR4 and thereby inhibiting the activation of TLR4-dependent signaling pathways. Over-expression of miR-146a may be useful in the prevention and treatment of atherosclerosis. | lld:pubmed |
| pubmed-article:21329689 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21329689 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21329689 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:21329689 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21329689 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21329689 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:21329689 | pubmed:issn | 1873-3468 | lld:pubmed |
| pubmed-article:21329689 | pubmed:author | pubmed-author:JobEE | lld:pubmed |
| pubmed-article:21329689 | pubmed:author | pubmed-author:LiuJingJ | lld:pubmed |
| pubmed-article:21329689 | pubmed:author | pubmed-author:KeYangY | lld:pubmed |
| pubmed-article:21329689 | pubmed:author | pubmed-author:SunZhenZ | lld:pubmed |
| pubmed-article:21329689 | pubmed:author | pubmed-author:ShenWei... | lld:pubmed |
| pubmed-article:21329689 | pubmed:author | pubmed-author:ChenQiu... | lld:pubmed |
| pubmed-article:21329689 | pubmed:author | pubmed-author:WangXiao... | lld:pubmed |
| pubmed-article:21329689 | pubmed:author | pubmed-author:HeYu SongYS | lld:pubmed |
| pubmed-article:21329689 | pubmed:copyrightInfo | Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | lld:pubmed |
| pubmed-article:21329689 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21329689 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:21329689 | pubmed:volume | 585 | lld:pubmed |
| pubmed-article:21329689 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21329689 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21329689 | pubmed:pagination | 854-60 | lld:pubmed |
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| pubmed-article:21329689 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21329689 | pubmed:articleTitle | MiR-146a inhibits oxidized low-density lipoprotein-induced lipid accumulation and inflammatory response via targeting toll-like receptor 4. | lld:pubmed |
| pubmed-article:21329689 | pubmed:affiliation | Department of Cardiology, Rui Jin Hospital, Jiaotong University School of Medicine, Shanghai 200025, People's Republic of China. | lld:pubmed |
| pubmed-article:21329689 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21329689 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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