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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2011-3-15
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pubmed:abstractText |
Atherosclerosis is an inflammatory process due to oxidized low-density lipoprotein (oxLDL) accumulation in macrophages. We investigated the involvement of microRNAs in oxLDL accumulation and inflammatory response in macrophages. The expression of miR-146a decreases under oxLDL stimulation. MiR-146a significantly reduces intracellular LDL cholesterol content and secretion of interleukin 6, interleukin 8, chemokine (C-C motif) ligand 2 and matrix metallopeptidase 9. Toll-like receptor 4 (TLR4) is a relevant target of miR-146a, and miR-146a inhibits the activation of TLR4-dependent intracellular signaling pathways involved in cytoskeleton rearrangement, lipid uptake, and inflammatory cytokine secretion. These results indicate that miR-146a contributes to the regulation of both oxLDL accumulation and inflammatory response by negatively regulating TLR4 and thereby inhibiting the activation of TLR4-dependent signaling pathways. Over-expression of miR-146a may be useful in the prevention and treatment of atherosclerosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3' Untranslated Regions,
http://linkedlifedata.com/resource/pubmed/chemical/CCL2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL2,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Inflammation Mediators,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-8,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/MIRN146 microRNA, human,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 9,
http://linkedlifedata.com/resource/pubmed/chemical/MicroRNAs,
http://linkedlifedata.com/resource/pubmed/chemical/TLR4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 4,
http://linkedlifedata.com/resource/pubmed/chemical/oxidized low density lipoprotein
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1873-3468
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
23
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pubmed:volume |
585
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
854-60
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pubmed:meshHeading |
pubmed-meshheading:21329689-3' Untranslated Regions,
pubmed-meshheading:21329689-Base Sequence,
pubmed-meshheading:21329689-Cell Line,
pubmed-meshheading:21329689-Chemokine CCL2,
pubmed-meshheading:21329689-Cholesterol, LDL,
pubmed-meshheading:21329689-Cytokines,
pubmed-meshheading:21329689-Cytoskeleton,
pubmed-meshheading:21329689-Gene Expression Profiling,
pubmed-meshheading:21329689-HeLa Cells,
pubmed-meshheading:21329689-Humans,
pubmed-meshheading:21329689-Inflammation Mediators,
pubmed-meshheading:21329689-Interleukin-6,
pubmed-meshheading:21329689-Interleukin-8,
pubmed-meshheading:21329689-Lipoproteins, LDL,
pubmed-meshheading:21329689-Macrophages,
pubmed-meshheading:21329689-Matrix Metalloproteinase 9,
pubmed-meshheading:21329689-MicroRNAs,
pubmed-meshheading:21329689-Mutation,
pubmed-meshheading:21329689-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:21329689-RNA Interference,
pubmed-meshheading:21329689-Signal Transduction,
pubmed-meshheading:21329689-Toll-Like Receptor 4
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pubmed:year |
2011
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pubmed:articleTitle |
MiR-146a inhibits oxidized low-density lipoprotein-induced lipid accumulation and inflammatory response via targeting toll-like receptor 4.
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pubmed:affiliation |
Department of Cardiology, Rui Jin Hospital, Jiaotong University School of Medicine, Shanghai 200025, People's Republic of China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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