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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1991-4-26
|
| pubmed:abstractText |
Metabolism in vivo of 3,4,5,3',4'-pentachlorobiphenyl (PenCB) and toxicological assessment of the metabolite were investigated using male Wistar rats. Only one metabolite was isolated from the feces of rats administered 3,4,5,3',4'-PenCB. By gas chromatography-mass spectrometry, the methylated metabolite was identified with the synthesized authentic sample, 4'-methoxy-3,4,5,3',5'-PenCB. This indicated that the metabolite was 4'-hydroxy-3,4,5,3',5'-PenCB, which was produced via a 4',5'-epoxide formation and subsequent NIH-shift of the 4'-chlorine to the 5'-position. Administration of the metabolite at either single i.p. dose of 3 or 10 mg/kg to rats did not cause any toxic and biological effects such as body weight loss, atrophy of thymus and spleen, liver hypertrophy, increase of liver lipids, or 3-methylcholanthrene-type induction of liver enzymes. These changes were observed in rats administered with 3,4,5,3',4'-PenCB at a single dose of 3 mg/kg. In addition, a trace amount of 4'-hydroxy-3,4,5,3',5'-PenCB could be detected in rat liver 5 d after treatment with 3,4,5,3',4'-PenCB or 4'-hydroxy-3,4,5,3',5'-PenCB. The amount of this metabolite excreted in feces during 5 d after treatment with 3,4,5,3',4'-PenCB accounted for only 1.3% of dose. In 4'-hydroxy-3,4,5,3',5'-PenCB-treated rats, about 60% of dose was excreted as unchanged in feces for 5 d. These results suggest that this metabolite is a detoxified product and has no longer the high affinity for the liver, being excreted rapidly into the feces.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0386-846X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
497-506
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2132573-Animals,
pubmed-meshheading:2132573-Chromatography, Thin Layer,
pubmed-meshheading:2132573-Enzyme Induction,
pubmed-meshheading:2132573-Feces,
pubmed-meshheading:2132573-Liver,
pubmed-meshheading:2132573-Male,
pubmed-meshheading:2132573-Organ Size,
pubmed-meshheading:2132573-Polychlorinated Biphenyls,
pubmed-meshheading:2132573-Rats,
pubmed-meshheading:2132573-Rats, Inbred Strains
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Metabolism in vivo of 3,4,5,3',4'-pentachlorobiphenyl and toxicological assessment of the metabolite in rats.
|
| pubmed:affiliation |
Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|