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pubmed:abstractText |
The lysis-lysogeny decision in the temperate coliphage ? is influenced by a number of phage proteins (CII and CIII) as well as host factors, viz. Escherichia coli HflB, HflKC and HflD. Prominent among these are the transcription factor CII and HflB, an ATP-dependent protease that degrades CII. Stabilization of CII promotes lysogeny, while its destabilization induces the lytic mode of development. All other factors that influence the lytic/lysogenic decision are known to act by their effects on the stability of CII. Deletion of hflKC has no effect on the stability of CII. However, when ? infects ?hflKC cells, turbid plaques are produced, indicating stabilization of CII under these conditions.
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pubmed:affiliation |
Department of Biochemistry, Bose Institute, P 1/12, C,I,T, Scheme VIIM, Kolkata 700 054, India.
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