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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0024109,
umls-concept:C0024117,
umls-concept:C0030705,
umls-concept:C0038172,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0442739,
umls-concept:C1419789,
umls-concept:C1446409,
umls-concept:C1511790,
umls-concept:C1815389,
umls-concept:C2346711,
umls-concept:C2911684
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pubmed:dateCreated |
2011-3-9
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pubmed:abstractText |
Progressive airway inflammation and susceptibility to the airway colonisation and infection are characteristic for the pathophysiology of chronic obstructive pulmonary disease (COPD). Antimicrobial peptides (AMPs) are central to the function of the innate host immune response against microbial pathogens and are regulators of inflammation and immunity. S100A7/psoriasin, a recently described AMP, is an essential component of the human epithelia against invading pathogens and acts as an effector molecule of the host innate defence in the skin. We hypothesized that S100A7/psoriasin is involved in the airway mucosal immunity and differently regulated and expressed in the lung during progression of COPD.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21324122-10719668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21324122-11316667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21324122-11795830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21324122-11991838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21324122-14999112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21324122-15162262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21324122-15191538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21324122-16236163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21324122-16262268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21324122-16269090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21324122-16497588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21324122-16787176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21324122-17436190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21324122-17507545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21324122-18075823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21324122-18263703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21324122-18364444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21324122-18373864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21324122-18625016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21324122-18634149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21324122-3492164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21324122-8701470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21324122-9038346
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2466
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10
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pubmed:dateRevised |
2011-7-26
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pubmed:meshHeading |
pubmed-meshheading:21324122-Adult,
pubmed-meshheading:21324122-Aged,
pubmed-meshheading:21324122-Aged, 80 and over,
pubmed-meshheading:21324122-Biopsy,
pubmed-meshheading:21324122-Bronchi,
pubmed-meshheading:21324122-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:21324122-Case-Control Studies,
pubmed-meshheading:21324122-Female,
pubmed-meshheading:21324122-Humans,
pubmed-meshheading:21324122-Immunity, Innate,
pubmed-meshheading:21324122-Lung,
pubmed-meshheading:21324122-Male,
pubmed-meshheading:21324122-Middle Aged,
pubmed-meshheading:21324122-Pulmonary Disease, Chronic Obstructive,
pubmed-meshheading:21324122-RNA, Messenger,
pubmed-meshheading:21324122-S100 Proteins,
pubmed-meshheading:21324122-Staphylococcal Infections,
pubmed-meshheading:21324122-Staphylococcus aureus
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pubmed:year |
2011
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pubmed:articleTitle |
S100A7/psoriasin expression in the human lung: unchanged in patients with COPD, but upregulated upon positive S. aureus detection.
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pubmed:affiliation |
Division of Innate Immunity, Department of Immunology and Cell Biology, Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Parkallee 1-40, 23845 Borstel, Germany. hheine@fz-borstel.de.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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