Linked Life Data

21308877

Source:http://linkedlifedata.com/resource/pubmed/id/21308877

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2011-2-10
pubmed:abstractText
Gramicidin S (GS) is a cyclo-decapeptide antibiotic isolated from Bacillus brevis. The structural studies have shown that GS forms a two-stranded antiparallel ?-sheet imposed by two II' ?-turns. Despite its wide Gram+ and Gram- antimicrobial spectrum, GS is useless in therapy because of its high hemotoxicity in humans. It was found, however, that the analogues of GS-14 (GS with 14 amino acid residues) attained a better antimicrobial selectivity when their amphipatic moments were perturbed. In this study, we report effects of similar perturbations imposed on GS cyclo-decapeptide analogues. Having solved their structures by NMR/molecular dynamics and having tested their activities/selectivities, we have concluded that the idea of perturbation of the amphipatic moment does not work for GS-10_0 analogues. An innovative approach to the synthesis of head-to-tail cyclopeptides was used.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1099-1387
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 European Peptide Society and John Wiley & Sons, Ltd.
pubmed:issnType
Electronic
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
211-7
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Synthesis, biological activity and solution structure of new analogues of the antimicrobial Gramicidin S.
pubmed:affiliation
University of Gda?sk, Faculty of Chemistry, Sobieskiego 18, Gda?sk, 80-952, Poland. kamysz@chem.univ.gda.pl
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't