21303498

Source:http://linkedlifedata.com/resource/pubmed/id/21303498

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0003320, umls-concept:C0005767, umls-concept:C0012854, umls-concept:C0021311, umls-concept:C0024400, umls-concept:C0024530, umls-concept:C0032868, umls-concept:C0042196, umls-concept:C0205245, umls-concept:C0205263, umls-concept:C0474643, umls-concept:C0562648, umls-concept:C0679199, umls-concept:C0805586, umls-concept:C1287242, umls-concept:C1306673, umls-concept:C1511253
pubmed:issue	1
pubmed:dateCreated	2011-3-2
pubmed:abstractText	A DNA prime, poxvirus (COPAK) boost vaccination regime with four antigens, i.e. a combination of two Plasmodium knowlesi sporozoite (csp/ssp2) and two blood stage (ama1/msp142) genes, leads to self-limited parasitaemia in 60% of rhesus monkeys and survival from an otherwise lethal infection with P. knowlesi. In the present study, the role of the blood stage antigens in protection was studied in depth, focusing on antibody formation against the blood stage antigens and the functionality thereof.
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101139802
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Protozoan, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Protozoan, http://linkedlifedata.com/resource/pubmed/chemical/Malaria Vaccines, http://linkedlifedata.com/resource/pubmed/chemical/Protozoan Proteins
pubmed:status	MEDLINE
pubmed:issn	1475-2875
pubmed:author	pubmed-author:El HassanIbrahim MIM, pubmed-author:FaberBart WBW, pubmed-author:HamidMuzamil Mahdi AbdelMM, pubmed-author:HussainAyman AAA, pubmed-author:KockenClemens H MCH, pubmed-author:NarumDavid LDL, pubmed-author:RemarqueEdmond JEJ, pubmed-author:ThomasAlan WAW, pubmed-author:WeissWalter RWR
pubmed:issnType	Electronic
pubmed:volume	10
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	29
pubmed:dateRevised	2011-7-26
pubmed:meshHeading	pubmed-meshheading:21303498-Animals, pubmed-meshheading:21303498-Antibodies, Protozoan, pubmed-meshheading:21303498-Antigens, Protozoan, pubmed-meshheading:21303498-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:21303498-Immunization, Secondary, pubmed-meshheading:21303498-Macaca mulatta, pubmed-meshheading:21303498-Malaria, pubmed-meshheading:21303498-Malaria Vaccines, pubmed-meshheading:21303498-Plasmids, pubmed-meshheading:21303498-Plasmodium knowlesi, pubmed-meshheading:21303498-Poxviridae, pubmed-meshheading:21303498-Protozoan Proteins, pubmed-meshheading:21303498-Sporozoites, pubmed-meshheading:21303498-Treatment Outcome
pubmed:year	2011
pubmed:articleTitle	Malaria infection by sporozoite challenge induces high functional antibody titres against blood stage antigens after a DNA prime, poxvirus boost vaccination strategy in Rhesus macaques.
pubmed:affiliation	Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands. faber@bprc.nl
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Intramural