Linked Life Data

21302207

Source:http://linkedlifedata.com/resource/pubmed/id/21302207

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2011-2-8
pubmed:abstractText
The human leukocyte antigen (HLA) B27 has been linked to rheumatic diseases such as ankylosing spondylitis nearly 40 years ago, but its role in pathogenesis remains unclear. Apart from this association, HLA-B27 has a positive effect in two of the most threatening human viral infections: in HIV infection, HLA-B27 positive patients have low viral loads, CD4+ T cell counts decline slowly and AIDS progresses slowly. In acute hepatitis C virus (HCV) infection, HLA-B27 is associated with a very high rate of spontaneous viral clearance. The mechanisms of protection by HLA-B27 in HIV and HCV infection have been characterized in the recent years and will be discussed in this article.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1439-4413
pubmed:author
pubmed:copyrightInfo
© Georg Thieme Verlag KG Stuttgart · New York.
pubmed:issnType
Electronic
pubmed:volume
136
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
320-4
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
[Protective role of HLA-B27 in HIV and hepatitis C virus infection].
pubmed:affiliation
Abteilung Innere Medizin II und Centrum für chronische Immundefizienz, Universitätsklinikum Freiburg, Freiburg. christoph.neumannhaefelin@uniklinik-freiburg.de
pubmed:publicationType
Journal Article, English Abstract, Review