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rdf:type |
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lifeskim:mentions |
umls-concept:C0001565,
umls-concept:C0005516,
umls-concept:C0018621,
umls-concept:C0020846,
umls-concept:C0021083,
umls-concept:C0039198,
umls-concept:C0150369,
umls-concept:C0205369,
umls-concept:C0220901,
umls-concept:C0439810,
umls-concept:C0442805,
umls-concept:C0456603,
umls-concept:C0871261,
umls-concept:C0996622,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
2011-3-28
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pubmed:abstractText |
The aims of this study were to examine the therapeutic effects of sublingual immunotherapy (SLIT) and to identify potential biomarkers that would predict the therapeutic response in a randomized, double-blind, placebo-controlled clinical trial. The trial was carried out over two pollinosis seasons in 2007 and 2008. Carry-over therapeutic effects were analyzed in 2009. SLIT significantly ameliorated the symptoms of pollinosis during the 2008 and 2009 pollen seasons. Cry j 1-specific cytokine production in a subgroup of patients with mild disease in the SLIT group was significantly attenuated. The ratio of specific IgE to total IgE before treatment correlated with the symptom-medication score in the SLIT group in 2008. Patients with increased Cry j 1-iTreg in the SLIT group had significantly improved QOL and QOL-symptom scores. In summary, the specific IgE to total IgE ratio and upregulation of Cry j 1-iTreg are candidates for biomarker of the clinical response to SLIT.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1521-7035
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pubmed:author |
pubmed-author:FujimuraTakashiT,
pubmed-author:HoriguchiShigetoshiS,
pubmed-author:InamineAyakoA,
pubmed-author:NakayamaToshinoriT,
pubmed-author:OkamotoYoshitakaY,
pubmed-author:SaitoAkemiA,
pubmed-author:SakaguchiMasahiroM,
pubmed-author:TakemoriToshitadaT,
pubmed-author:TaniguchiMasaruM,
pubmed-author:TaniguchiYurikoY,
pubmed-author:YasuedaHiroshiH,
pubmed-author:YonekuraSyujiS
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
139
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
65-74
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pubmed:meshHeading |
pubmed-meshheading:21300571-Administration, Sublingual,
pubmed-meshheading:21300571-Adolescent,
pubmed-meshheading:21300571-Adult,
pubmed-meshheading:21300571-Aged,
pubmed-meshheading:21300571-Antibody Specificity,
pubmed-meshheading:21300571-Biological Markers,
pubmed-meshheading:21300571-Cryptomeria,
pubmed-meshheading:21300571-Cytokines,
pubmed-meshheading:21300571-Double-Blind Method,
pubmed-meshheading:21300571-Female,
pubmed-meshheading:21300571-Gene Expression Regulation,
pubmed-meshheading:21300571-Humans,
pubmed-meshheading:21300571-Immunoglobulin E,
pubmed-meshheading:21300571-Male,
pubmed-meshheading:21300571-Middle Aged,
pubmed-meshheading:21300571-Plant Extracts,
pubmed-meshheading:21300571-Pollen,
pubmed-meshheading:21300571-Rhinitis, Allergic, Seasonal,
pubmed-meshheading:21300571-T-Lymphocytes, Regulatory,
pubmed-meshheading:21300571-Young Adult
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pubmed:year |
2011
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pubmed:articleTitle |
Increase of regulatory T cells and the ratio of specific IgE to total IgE are candidates for response monitoring or prognostic biomarkers in 2-year sublingual immunotherapy (SLIT) for Japanese cedar pollinosis.
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pubmed:affiliation |
Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohara, Chiba, Japan.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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