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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1991-11-13
|
| pubmed:abstractText |
The muscarinic antagonist scopolamine was injected into the prefrontal cortex and hippocampus of rats that were well trained in an operant delayed non-matching to position task. Cholinergic antagonism in the hippocampus induced dose- and delay-dependent deficits, characteristic of impaired short-term retention. By contrast, cholinergic antagonism in the prefrontal cortex induced dose-dependent but delay-independent deficits, suggesting disturbance of some non-mnemonic regulatory process in the neocortex.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0959-4965
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
1
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
61-4
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2129859-Animals,
pubmed-meshheading:2129859-Cerebral Cortex,
pubmed-meshheading:2129859-Conditioning, Operant,
pubmed-meshheading:2129859-Dose-Response Relationship, Drug,
pubmed-meshheading:2129859-Female,
pubmed-meshheading:2129859-Food Deprivation,
pubmed-meshheading:2129859-Hippocampus,
pubmed-meshheading:2129859-Memory, Short-Term,
pubmed-meshheading:2129859-Parasympatholytics,
pubmed-meshheading:2129859-Rats,
pubmed-meshheading:2129859-Rats, Inbred Strains,
pubmed-meshheading:2129859-Scopolamine Hydrobromide
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Cholinergic blockade in prefrontal cortex and hippocampus disrupts short-term memory in rats.
|
| pubmed:affiliation |
Department of Experimental Psychology, University of Cambridge, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|