Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-6-4
pubmed:abstractText
Antisera to epi- and trypomastigote forms of Trypanosoma cruzi were used to detect trypanosome antigens on the surface of lymphocytes from infected mice. Only the anti-trypomastigote serum could recognize antigens expressed transiently on the splenocyte membranes from infected animals. The number or structural configuration of Concanavalin A receptors was similarly affected and a clear correlation was seen between these two types of membrane changes and the immunosuppression to mitogens and SRBC presented by the infected mice. Reinfected animals did not show evidences of trypanosome proliferation in blood or tissues nor trypomastigote antigens on splenocytes, but presented a less intense, transient immunosuppression as measured by responsiveness to mitogens and SRBC, suggesting that the primed immune system can eliminate the new parasite inoculum before the host is immunosuppressed and also that the liberation of strong immunosuppressor trypomastigote antigens induce the new state of suppression.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0535-5133
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
17-31
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Splenocyte membrane changes and immunosuppression during infection and reinfection with Trypanosoma cruzi.
pubmed:affiliation
Centre of Microbiology and Cell Biology, Instituto Venezolano de Investigaciones Científicas (IVIC), Caracas, Venezuela.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't