Linked Life Data

21274863

Source:http://linkedlifedata.com/resource/pubmed/id/21274863

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-1-28
pubmed:abstractText
Chronic hepatitis B virus (HBV) infection is a major health issue, especially in Asia. A recent genome-wide association study (GWAS) implicated genetic variants in the human leukocyte antigen (HLA)-DP locus associated with chronic hepatitis B in Japanese and Thai populations. To confirm whether the polymorphisms at the HLA-DP genes are associated with persistent chronic HBV infection in Han Chinese, we conducted an independent case-control study using 521 persistent chronic HBV carriers and 819 controls that included 571 persons with HBV natural clearance and 248 never HBV-infected (healthy) individuals. Eleven single nucleotide polymorphisms (SNPs) in a region including HLA-DPA and HLA-DPB and an adjacent SNP in strong linkage disequilibrium (LD) with a neighboring HLA-DR13 locus were genotyped using the TaqMan SNP genotyping assay. Eleven variants at HLA-DP showed a strong association with persistent chronic HBV carrier status (P = 1.82 × 10(-12) to 0.01). We also stratified the analysis by HBV clearance status to test the association between these polymorphisms and HBV natural clearance; similar results were obtained (P = 2.70 × 10(-11) to 0.003). Included SNPs define highly structured haplotypes that were also strongly associated with HBV chronic infection (block 1: odds ratio [OR] = 0.54, P = 8.73 × 10(-7) ; block 2: OR = 1.98, P = 1.37 × 10(-10) ). These results further confirm that genetic variants in the HLA-DP locus are strongly associated with persistent HBV infection in the Han Chinese population.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1527-3350
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 American Association for the Study of Liver Diseases.
pubmed:issnType
Electronic
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
422-8
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:21274863-Adult, pubmed-meshheading:21274863-Carrier State, pubmed-meshheading:21274863-Case-Control Studies, pubmed-meshheading:21274863-China, pubmed-meshheading:21274863-Female, pubmed-meshheading:21274863-Genetic Predisposition to Disease, pubmed-meshheading:21274863-HLA-DP Antigens, pubmed-meshheading:21274863-HLA-DP alpha-Chains, pubmed-meshheading:21274863-HLA-DP beta-Chains, pubmed-meshheading:21274863-HLA-DR Antigens, pubmed-meshheading:21274863-HLA-DR Serological Subtypes, pubmed-meshheading:21274863-Haplotypes, pubmed-meshheading:21274863-Hepatitis B, Chronic, pubmed-meshheading:21274863-Hepatitis B virus, pubmed-meshheading:21274863-Humans, pubmed-meshheading:21274863-Linkage Disequilibrium, pubmed-meshheading:21274863-Male, pubmed-meshheading:21274863-Middle Aged, pubmed-meshheading:21274863-Polymorphism, Single Nucleotide
pubmed:year
2011
pubmed:articleTitle
Strong influence of human leukocyte antigen (HLA)-DP gene variants on development of persistent chronic hepatitis B virus carriers in the Han Chinese population.
pubmed:affiliation
Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Science, Wenzhou Medical College, Zhejiang, China. xguo1@cdc.gov
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural