Linked Life Data

21272650

Source:http://linkedlifedata.com/resource/pubmed/id/21272650

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2011-3-7
pubmed:databankReference
pubmed:abstractText
In this study we report the identification and characterization of channel catfish, Ictalurus punctatus CD8? and CD8? genes. Both genes encode predicted proteins containing a leader, a immunoglobulin superfamily V domain, a stalk/hinge region, a transmembrane region and a positively charged cytoplasmic tail (CYT) containing the conserved teleost C-X-H motif. Catfish CD8? and CD8? are encoded as single copy genes and as in other vertebrates exhibit a conserved head to tail synteny; the CD8? gene is found 14.1kb upstream of the CD8? gene. Both CD8? and CD8? transcripts showed a low degree of polymorphism. Finally, as determined by q-PCR both CD8? and CD8? are expressed in various catfish lymphoid tissues with the highest expression observed in thymus from 2 month old catfish-fry. In the future these results will provide the basis for evaluating the role of CD8(+) CTL and other CD8-bearing cells in response to immunization or infection in the catfish.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1095-9947
pubmed:author
pubmed:copyrightInfo
Published by Elsevier Ltd.
pubmed:issnType
Electronic
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
894-901
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Channel catfish CD8? and CD8? co-receptors: characterization, expression and polymorphism.
pubmed:affiliation
Sylvie.Quiniou@ARS.USDA.GOV
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.