Source:http://linkedlifedata.com/resource/pubmed/id/21266206
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0003595,
umls-concept:C0004083,
umls-concept:C0007226,
umls-concept:C0012155,
umls-concept:C0035647,
umls-concept:C0086860,
umls-concept:C0205349,
umls-concept:C0262950,
umls-concept:C0489488,
umls-concept:C0597423,
umls-concept:C0599883,
umls-concept:C0678594,
umls-concept:C1882417,
umls-concept:C2603343
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| pubmed:issue |
5
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| pubmed:dateCreated |
2011-4-18
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| pubmed:abstractText |
Association of apolipoprotein E (APOE) ?4 allele with peripheral quantitative computed tomography (pQCT) bone traits at the distal and shaft sites of the radius and tibia was evaluated in the Young Finns Cohort (n=1777). We also analyzed the interactions of the APOE promoter polymorphisms (-219G/T rs405509 and +113G/C rs440446) and bone traits within the APOE ?3/?3 genotype (n=1025 and n=1013, respectively), and investigated the gene-environment interactions on bone traits with longitudinal saturated fatty acids (SAFA) intake. Differences between the ?4 allele carriers and noncarriers were modest and mostly nonsignificant. Within the APOE promoter -219G/T polymorphism, cortical strength index (CSI) and compressive bone strength index (BSI) at the distal radius (linear, P=0.003 and P=0.05, respectively) and tibia (linear, P=0.01 and P=0.03, respectively), and CSI at the tibial shaft (linear, P=0.04) decreased towards the -219T/T genotype in women. In men, total cross-sectional areas at the radial site and stress-strain index (SSI) at the radial shaft (linear, P=0.03 and P=0.04 and P=0.05, respectively) increased, and conversely cortical bone density and CSI at the radial shaft (linear, P=0.005 and P=0.05, respectively) and CSI at the tibial shaft (linear, P=0.03) decreased towards the -219T/T genotype. In the highest SAFA tertile, women with the -219T/T genotype had the smallest total area and SSI at the radial shaft (P=0.01 and P=0.02, respectively). Subjects with the APOE +113C/C genotype shared similar bone traits as subjects with the APOE -219T/T genotype. In conclusion, APOE genotypes -219T/T and +113C/C could be genetic markers for cortical bone strength. Furthermore, high longitudinal SAFA intake seems to be more detrimental to bone in women with the -219T/T and +133C/C genotypes than others.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
1873-2763
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| pubmed:author |
pubmed-author:HernesniemiJussiJ,
pubmed-author:KähönenMikaM,
pubmed-author:LaaksonenMarikaM,
pubmed-author:LehtimäkiTerhoT,
pubmed-author:MikkiläVeraV,
pubmed-author:MononenNinaN,
pubmed-author:RaitakariOlliO,
pubmed-author:SievänenHarriH,
pubmed-author:TolonenSannaS,
pubmed-author:VehkalahtiKimmoK,
pubmed-author:ViikariJormaJ
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| pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:day |
1
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| pubmed:volume |
48
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1058-65
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| pubmed:dateRevised |
2011-10-2
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| pubmed:meshHeading |
pubmed-meshheading:21266206-Adolescent,
pubmed-meshheading:21266206-Adult,
pubmed-meshheading:21266206-Apolipoproteins E,
pubmed-meshheading:21266206-Bone and Bones,
pubmed-meshheading:21266206-Cardiovascular Diseases,
pubmed-meshheading:21266206-Child,
pubmed-meshheading:21266206-Child, Preschool,
pubmed-meshheading:21266206-Cholesterol,
pubmed-meshheading:21266206-Dietary Fats,
pubmed-meshheading:21266206-Fatty Acids,
pubmed-meshheading:21266206-Feeding Behavior,
pubmed-meshheading:21266206-Female,
pubmed-meshheading:21266206-Finland,
pubmed-meshheading:21266206-Gene Frequency,
pubmed-meshheading:21266206-Heterozygote,
pubmed-meshheading:21266206-Humans,
pubmed-meshheading:21266206-Male,
pubmed-meshheading:21266206-Middle Aged,
pubmed-meshheading:21266206-Polymorphism, Single Nucleotide,
pubmed-meshheading:21266206-Promoter Regions, Genetic,
pubmed-meshheading:21266206-Radius,
pubmed-meshheading:21266206-Risk Factors,
pubmed-meshheading:21266206-Tibia
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| pubmed:year |
2011
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| pubmed:articleTitle |
Association of apolipoprotein E promoter polymorphisms with bone structural traits is modified by dietary saturated fat intake - the Cardiovascular Risk in Young Finns study.
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| pubmed:affiliation |
Department of Food and Environmental Sciences, University of Helsinki, Finland.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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