Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-1-25
pubmed:abstractText
A series of 2-[2-(2,6-dichlorophenyl)amino]benzyl-3-(5-substituted phenyl-4,5-dihydro-1H-pyrazol-3-yl-amino)-6,8-dibromoquinazolin-4(3H) ones 6a-m have been synthesized by the reaction of 2-[2-(2,6-dichlorophenyl)amino]benzyl-3-substituted phenylacrylamido-6,8-dibromoquinazolin-4(3H) ones 5a-m with hydrazine hydrate in the presence of glacial acetic acid. The chalcones 5a-m were prepared by the condensation of 2-[2-(2,6-dichlorophenyl)amino]benzyl-3-acetamido-6,8-dibromoquinazolin-4(3H)one 4 with different substituted aromatic aldehyde. The benzoxazinone 2 was synthesized from 2-[2-(2,6-dichlorophenyl)amino]phenyl acetyl chloride 1 on treatment with 3,5-dibromoanthranilic acid in pyridine, which on reaction with hydrazine hydrate and then on acetylation reaction yielded 4. The structures of these compounds have been elucidated by elemental analyses, IR, and NMR spectral data. The title compounds pyrazolyl-quinazolin-4(3H)ones 6a-m were evaluated for their antibacterial and antifungal activities in vitro.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/21264122-10906414, http://linkedlifedata.com/resource/pubmed/commentcorrection/21264122-14604693, http://linkedlifedata.com/resource/pubmed/commentcorrection/21264122-14980637, http://linkedlifedata.com/resource/pubmed/commentcorrection/21264122-15051061, http://linkedlifedata.com/resource/pubmed/commentcorrection/21264122-16260068, http://linkedlifedata.com/resource/pubmed/commentcorrection/21264122-16460945, http://linkedlifedata.com/resource/pubmed/commentcorrection/21264122-17069933, http://linkedlifedata.com/resource/pubmed/commentcorrection/21264122-17125888, http://linkedlifedata.com/resource/pubmed/commentcorrection/21264122-17251028, http://linkedlifedata.com/resource/pubmed/commentcorrection/21264122-17317192, http://linkedlifedata.com/resource/pubmed/commentcorrection/21264122-18222569, http://linkedlifedata.com/resource/pubmed/commentcorrection/21264122-18321714, http://linkedlifedata.com/resource/pubmed/commentcorrection/21264122-18378360, http://linkedlifedata.com/resource/pubmed/commentcorrection/21264122-18922604, http://linkedlifedata.com/resource/pubmed/commentcorrection/21264122-18986738, http://linkedlifedata.com/resource/pubmed/commentcorrection/21264122-19000643, http://linkedlifedata.com/resource/pubmed/commentcorrection/21264122-19419804, http://linkedlifedata.com/resource/pubmed/commentcorrection/21264122-8691473
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
Apr
pubmed:issn
0975-1505
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
173-82
pubmed:dateRevised
2011-7-20
pubmed:year
2010
pubmed:articleTitle
Synthesis and Antimicrobial Activity of 2-[2-(2,6-dichloro phenyl)amino]benzyl-3-(5-substituted phenyl-4,5-dihydro-1H-pyrazol-3-yl-amino)-6,8-dibromoquinazolin-4(3H)ones.
pubmed:affiliation
Department of Chemistry, Veer Narmad South Gujarat University, Surat 395007, Gujarat, India.
pubmed:publicationType
Journal Article