Source:http://linkedlifedata.com/resource/pubmed/id/21254935
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2011-5-12
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| pubmed:abstractText |
Recent studies have identified a negative correlation between serum levels of insulin-like growth factor binding protein-3 (IGFBP-3) and the risk of lung cancer. In this study, polymorphisms present at the -1590 site of the IGFBP-3 promoter were evaluated in relation to lung cancer risk in a Chinese Han population. A total of 248 nonsmall cell lung cancer (NSCLC) cases and 29 small cell lung cancer cases were compared with 252 matched, healthy controls. Polymerase chain reaction-based restriction fragment length polymorphism assays were used to detect polymorphisms present. The A/A genotype and an A allele were both associated with an increased risk of NSCLC after being adjusted for age and gender (adjusted odds ratio?=?2.296, 95% confidence interval?=?1.133-4.655; and adjusted odds ratio?=?1.390, 95% confidence interval?=?1.042-1.854, respectively). In conclusion, the A/A genotype and A allele of the IGFBP-3 promoter -1590 site may represent a genetic risk factor for NSCLC, with the A/A genotype being associated with a higher risk for squamous cell carcinoma than adenocarcinoma.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
1945-0257
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
15
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
301-6
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| pubmed:meshHeading |
pubmed-meshheading:21254935-Adult,
pubmed-meshheading:21254935-Aged,
pubmed-meshheading:21254935-Asian Continental Ancestry Group,
pubmed-meshheading:21254935-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:21254935-Case-Control Studies,
pubmed-meshheading:21254935-China,
pubmed-meshheading:21254935-Female,
pubmed-meshheading:21254935-Genetic Predisposition to Disease,
pubmed-meshheading:21254935-Genotype,
pubmed-meshheading:21254935-Humans,
pubmed-meshheading:21254935-Insulin-Like Growth Factor Binding Protein 3,
pubmed-meshheading:21254935-Lung Neoplasms,
pubmed-meshheading:21254935-Male,
pubmed-meshheading:21254935-Middle Aged,
pubmed-meshheading:21254935-Polymorphism, Single Nucleotide,
pubmed-meshheading:21254935-Promoter Regions, Genetic,
pubmed-meshheading:21254935-Small Cell Lung Carcinoma
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| pubmed:year |
2011
|
| pubmed:articleTitle |
Association between insulin-like growth factor binding protein-3 promoter polymorphism of -1590 C>A and lung cancer susceptibility in a Chinese Han population.
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| pubmed:affiliation |
Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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