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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
1991-2-7
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pubmed:databankReference |
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pubmed:abstractText |
We report here that a point mutation in the gene which encodes the heterochromatin-specific nonhistone chromosomal protein HP-1 in Drosophila melanogaster is associated with dominant suppression of position-effect variegation. The mutation, a G-to-A transition at the first nucleotide of the last intron, causes missplicing of the HP-1 mRNA. This suggests that heterochromatin-specific proteins play a central role in the gene suppression associated with heterochromatic position effects.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-1055375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-2107402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-2448875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-2500281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-2505058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-2505764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-2515059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-2645293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-2880558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-291033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-2991899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-3030885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-3099166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-3146523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-3199441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-322279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-3615198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-3917855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-5014926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-6088070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-6279311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-6310323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-6312838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-6418386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-6795427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-6813058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-7151176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2124708-911786
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9923-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2124708-Alleles,
pubmed-meshheading:2124708-Amino Acid Sequence,
pubmed-meshheading:2124708-Animals,
pubmed-meshheading:2124708-Base Sequence,
pubmed-meshheading:2124708-Blotting, Southern,
pubmed-meshheading:2124708-Chromosomal Proteins, Non-Histone,
pubmed-meshheading:2124708-Cloning, Molecular,
pubmed-meshheading:2124708-DNA,
pubmed-meshheading:2124708-Drosophila melanogaster,
pubmed-meshheading:2124708-Gene Library,
pubmed-meshheading:2124708-Heterochromatin,
pubmed-meshheading:2124708-Molecular Sequence Data,
pubmed-meshheading:2124708-Mutation,
pubmed-meshheading:2124708-Oligonucleotide Probes,
pubmed-meshheading:2124708-Polymerase Chain Reaction,
pubmed-meshheading:2124708-Restriction Mapping,
pubmed-meshheading:2124708-Suppression, Genetic
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pubmed:year |
1990
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pubmed:articleTitle |
Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster.
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pubmed:affiliation |
E. A. Doisy Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, MO 63104.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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