Pralidoxime is an organic cation used as an antidote in addition to atropine to treat organophosphate poisoning. Pralidoxime is rapidly eliminated by the renal route and thus has limited action. The objectives of this work were as follows. 1) Study the role of organic cation transporters in the renal secretion of pralidoxime using organic cation transporter substrates (tetraethylammonium) and knockout mice (Oct1/2?/?; Oct3?/?). 2) Assess whether sustained high plasma concentrations increase pralidoxime antidotal activity toward paraoxon-induced respiratory toxicity.
Neuropsychopharmacologie des addictions, Faculty of Pharmacy, University Paris Descartes, CNRS, UMR8206, and University Denis Diderot, Paris, France. maya.kayouka@gmail.com
