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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-2-14
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pubmed:abstractText |
Blockade of aberrant hedgehog (Hh) activation has recently been proposed as a therapeutic target, but effects in models of islet cell tumors have not been examined. In this study, we address the role of the Hh pathway in tumor progression of murine islet cell tumors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1528-1140
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
253
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
546-52
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pubmed:meshHeading |
pubmed-meshheading:21239987-Adenoma, Islet Cell,
pubmed-meshheading:21239987-Animals,
pubmed-meshheading:21239987-Antigens, Polyomavirus Transforming,
pubmed-meshheading:21239987-Antineoplastic Agents,
pubmed-meshheading:21239987-Apoptosis,
pubmed-meshheading:21239987-Cell Division,
pubmed-meshheading:21239987-Cell Transformation, Neoplastic,
pubmed-meshheading:21239987-GTPase-Activating Proteins,
pubmed-meshheading:21239987-Hedgehog Proteins,
pubmed-meshheading:21239987-Humans,
pubmed-meshheading:21239987-Immunoenzyme Techniques,
pubmed-meshheading:21239987-Islets of Langerhans,
pubmed-meshheading:21239987-Male,
pubmed-meshheading:21239987-Mice,
pubmed-meshheading:21239987-Mice, Inbred C57BL,
pubmed-meshheading:21239987-Mice, Transgenic,
pubmed-meshheading:21239987-Pancreas,
pubmed-meshheading:21239987-Pancreatic Neoplasms,
pubmed-meshheading:21239987-Veratrum Alkaloids
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pubmed:year |
2011
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pubmed:articleTitle |
Hedgehog inhibition with cyclopamine represses tumor growth and prolongs survival in a transgenic mouse model of islet cell tumors.
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pubmed:affiliation |
Department of Surgery, Philipps-University Marburg, Germany. fendrich@med.uni-marburg.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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