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pubmed-article:2123430pubmed:abstractTextBecause some aldose reductase inhibitor studies have demonstrated clinical improvement in scored neurological signs and symptoms of diabetic neuropathy, a prospective study of the effect on cardiovascular performance of sorbinil 250 mg/day for 12 months was conducted on patients with diabetic autonomic neuropathy who were free of atherosclerotic coronary artery disease and/or cardiomyopathy. After 1 year of treatment, the study group (n = 14) demonstrated significant improvement in both the resting cardiac output (P = 0.02), and the maximal cardiac output (P = 0.03). This observation suggests that the use of an aldose reductase inhibitor may be useful in treating suboptimal cardiovascular performance in patients with diabetic cardiac autonomic neuropathy.lld:pubmed
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pubmed-article:2123430pubmed:articleTitleThe effect of an aldose reductase inhibitor on cardiovascular performance in patients with diabetes mellitus.lld:pubmed
pubmed-article:2123430pubmed:affiliationDiabetic Research Unit, Louisville Veterans Administration Medical Center, KY.lld:pubmed
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