|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1991-1-14
|
|
pubmed:abstractText |
Because some aldose reductase inhibitor studies have demonstrated clinical improvement in scored neurological signs and symptoms of diabetic neuropathy, a prospective study of the effect on cardiovascular performance of sorbinil 250 mg/day for 12 months was conducted on patients with diabetic autonomic neuropathy who were free of atherosclerotic coronary artery disease and/or cardiomyopathy. After 1 year of treatment, the study group (n = 14) demonstrated significant improvement in both the resting cardiac output (P = 0.02), and the maximal cardiac output (P = 0.03). This observation suggests that the use of an aldose reductase inhibitor may be useful in treating suboptimal cardiovascular performance in patients with diabetic cardiac autonomic neuropathy.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0168-8227
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
10
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
91-7
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:2123430-Adult,
pubmed-meshheading:2123430-Aldehyde Reductase,
pubmed-meshheading:2123430-Blood Pressure,
pubmed-meshheading:2123430-Cardiac Output,
pubmed-meshheading:2123430-Cardiovascular System,
pubmed-meshheading:2123430-Diabetes Mellitus, Type 1,
pubmed-meshheading:2123430-Diabetes Mellitus, Type 2,
pubmed-meshheading:2123430-Diabetic Neuropathies,
pubmed-meshheading:2123430-Epinephrine,
pubmed-meshheading:2123430-Female,
pubmed-meshheading:2123430-Heart Rate,
pubmed-meshheading:2123430-Humans,
pubmed-meshheading:2123430-Imidazoles,
pubmed-meshheading:2123430-Imidazolidines,
pubmed-meshheading:2123430-Male,
pubmed-meshheading:2123430-Middle Aged,
pubmed-meshheading:2123430-Nervous System Diseases,
pubmed-meshheading:2123430-Norepinephrine,
pubmed-meshheading:2123430-Prospective Studies
|
|
pubmed:articleTitle |
The effect of an aldose reductase inhibitor on cardiovascular performance in patients with diabetes mellitus.
|
|
pubmed:affiliation |
Diabetic Research Unit, Louisville Veterans Administration Medical Center, KY.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
