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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-1-24
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pubmed:abstractText |
A series of N-propyl-8-chloro-6-substituted isoquinolones was identified as positive allosteric modulators of metabotropic glutamate receptor 2 (mGluR2 PAM) via high throughput screening (HTS). The subsequent synthesis and initial SAR exploration that led to the identification of compound 28 is described.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:AndrésJosé IgnacioJI,
pubmed-author:CidJosé MaríaJM,
pubmed-author:CluzeauPhilippeP,
pubmed-author:D'AddonaDavidD,
pubmed-author:DuveyGuillaumeG,
pubmed-author:FinnTerryT,
pubmed-author:FurnariRoccoR,
pubmed-author:ImogaiHassanH,
pubmed-author:KarbalaieKK,
pubmed-author:LavreysenHildeH,
pubmed-author:Le PoulEmmanuelE,
pubmed-author:LutjensRobertR,
pubmed-author:MacdonaldGregor JGJ,
pubmed-author:NhemVantheaV,
pubmed-author:PoirierNicolasN,
pubmed-author:PoliSoniaS,
pubmed-author:PoulainGéraldineG,
pubmed-author:RauxAlexandreA,
pubmed-author:RocherJean-PhilippeJP,
pubmed-author:ThollonYvesY,
pubmed-author:TrabancoAndrés AAA
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
971-6
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pubmed:meshHeading |
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pubmed:year |
2011
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pubmed:articleTitle |
New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones.
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pubmed:affiliation |
Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag SA, Toledo, Spain. atrabanc@its.jnj.com
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pubmed:publicationType |
Journal Article
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