Linked Life Data

21221702

Source:http://linkedlifedata.com/resource/pubmed/id/21221702

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-2-24
pubmed:abstractText
Fever is often present during painful vaso-occlusive crisis (VOC) in sickle-cell disease (SCD), but does not always indicate infection. The aim of our study was to test procalcitonin as a marker of invasive bacterial infection in VOC. Consecutive SCD adults hospitalized for VOC were included. Data were collected at admission and within 24 h after the onset of fever. We distinguished patients with clinically defined and microbiologically documented invasive bacterial infection from patients with no evidence of invasive bacterial infection and who fared well without antibiotics. One hundred and twelve patients were enrolled (61% females, median age 23 years, 88% homozygous SCD). All patients with procalcitonin (PCT) level ?1 ?g/L had an invasive bacterial infection, but two patients (33%) with an invasive bacterial infection had a PCT level <1 ?g/L. High levels of PCT indicate invasive bacterial infection. However, a single low PCT level without follow-up measurement cannot rule out an invasive bacterial infection and should not withhold the prescription of antibiotics.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1439-0973
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
41-5
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Is procalcitonin a marker of invasive bacterial infection in acute sickle-cell vaso-occlusive crisis?
pubmed:affiliation
Service de Médecine Interne, Centre de Référence de la Drépanocytose Adulte, Assistance Publique-Hôpitaux de Paris, Hôpital Tenon, 4 rue de la Chine, Paris cedex 20, France. katia.stankovic@tnn.aphp.fr
pubmed:publicationType
Journal Article, Evaluation Studies