Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2011-2-21
pubmed:abstractText
Protein-transduction domains (PTDs) are short stretches of cationic amino acids that enable peptides, proteins, oligonucleotides, and other reagents to efficiently enter multiple cell types. Therefore, PTDs offer unique therapeutic opportunities for the treatment of many diseases. Previous studies examined the in vivo distribution of PTD-containing fusion proteins following administration via different routes, including portal vein, intravenous, intraperitoneal, and oral administration. Skin may be an appropriate target organ for this new molecular-carrier system; however, there are no studies on the in vivo kinetics and biological effects of PTD-containing proteins following intradermal application. Among the PTDs, poly-arginine peptides, especially nona-arginine (R9), is transported most efficiently with minimal cytotoxicity. Here, we review protein transduction technology from a different angle, as a novel tool in immunotherapeutic approaches to the skin cancers that depend on the biological characteristics of poly-arginine. This could be used in place of gene therapy for skin cancer patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1873-569X
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
153-61
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Novel immunotherapeutic approaches to skin cancer treatments using protein transduction technology.
pubmed:affiliation
Department of Dermatology, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan. naotakas@yamanashi.ac.jp
pubmed:publicationType
Journal Article, Review