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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-3-22
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pubmed:abstractText |
A novel mechanism of platelet destruction involving the CD47/ signal regulatory protein-? (SIRP?) system has recently been suggested in a mouse model of immune thrombocytopenia (ITP). The CD47 molecule serves as ligand for SIRP? receptor and as receptor for thrombospondin acting as antagonistic to phagocyte activity and a regulator of apoptosis, respectively. In this study, we evaluated if the CD47/SIRP? axis may be involved in the apoptosis and clearance of platelets in human ITP.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD14,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD47,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/SIRPA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Thrombospondin 1
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1873-2399
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
486-94
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pubmed:meshHeading |
pubmed-meshheading:21211546-Adult,
pubmed-meshheading:21211546-Aged,
pubmed-meshheading:21211546-Antibodies,
pubmed-meshheading:21211546-Antigens, CD14,
pubmed-meshheading:21211546-Antigens, CD47,
pubmed-meshheading:21211546-Antigens, Differentiation,
pubmed-meshheading:21211546-Apoptosis,
pubmed-meshheading:21211546-Blood Platelets,
pubmed-meshheading:21211546-Cells, Cultured,
pubmed-meshheading:21211546-Dendritic Cells,
pubmed-meshheading:21211546-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:21211546-Female,
pubmed-meshheading:21211546-Flow Cytometry,
pubmed-meshheading:21211546-Humans,
pubmed-meshheading:21211546-Macrophages,
pubmed-meshheading:21211546-Male,
pubmed-meshheading:21211546-Middle Aged,
pubmed-meshheading:21211546-Phagocytosis,
pubmed-meshheading:21211546-Receptors, Immunologic,
pubmed-meshheading:21211546-Signal Transduction,
pubmed-meshheading:21211546-Thrombocytopenia,
pubmed-meshheading:21211546-Thrombospondin 1,
pubmed-meshheading:21211546-Time Factors,
pubmed-meshheading:21211546-Young Adult
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pubmed:year |
2011
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pubmed:articleTitle |
The CD47 pathway is deregulated in human immune thrombocytopenia.
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pubmed:affiliation |
Department of Hematology and Oncological Sciences L. & A. Seràgnoli, Institute of Hematology, University of Bologna, Bologna, Italy. lucia.catani@unibo.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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