The B-DNA major and minor groove dimensions are crucial for DNA-protein interactions. It has long been thought that the groove dimensions depend on the DNA sequence, however this relationship has remained elusive. Here, our aim is to elucidate how the DNA sequence intrinsically shapes the grooves.
Laboratoire de Physique Théorique et Modélisation, UMR-8089, Centre National de la Recherche Scientifique et Université de Cergy-Pontoise, Cergy-Pontoise, France.
