Linked Life Data

21204585

Source:http://linkedlifedata.com/resource/pubmed/id/21204585

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-2-22
pubmed:abstractText
Combination of two or more therapeutic strategies with different mechanisms can cooperatively prohibit cancer development. Combination of chemotherapy and small interfering RNA (siRNA)-based therapy represents an example of this approach. Hypothesizing that the chemotherapeutic drug and the siRNA should be simultaneously delivered to the same tumoral cell to exert their synergistic effect, the development of delivery systems that can efficiently encapsulate two drugs and successfully deliver payloads to targeted sites via systemic administration has proven to be challenging. Here, we demonstrate an innovative "two-in-one" micelleplex approach based on micellar nanoparticles of a biodegradable triblock copolymer poly(ethylene glycol)-b-poly(?-caprolactone)-b-poly(2-aminoethyl ethylene phosphate) to systemically deliver the siRNA and chemotherapeutic drug. We show clear evidence that the micelleplex is capable of delivering siRNA and paclitaxel simultaneously to the same tumoral cells both in vitro and in vivo. We further demonstrate that systemic administration of the micelleplex carrying polo-like kinase 1 (Plk1) specific siRNA and paclitaxel can induce a synergistic tumor suppression effect in the MDA-MB-435s xenograft murine model, requiring a thousand-fold less paclitaxel than needed for paclitaxel monotherapy delivered by the micelleplex and without activation of the innate immune response or generation of carrier-associated toxicity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1936-086X
pubmed:author
pubmed:issnType
Electronic
pubmed:day
22
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1483-94
pubmed:dateRevised
2011-11-2
pubmed:meshHeading
pubmed-meshheading:21204585-Animals, pubmed-meshheading:21204585-Base Sequence, pubmed-meshheading:21204585-Cell Cycle Proteins, pubmed-meshheading:21204585-Cell Line, Tumor, pubmed-meshheading:21204585-Dose-Response Relationship, Drug, pubmed-meshheading:21204585-Drug Carriers, pubmed-meshheading:21204585-Drug Synergism, pubmed-meshheading:21204585-Female, pubmed-meshheading:21204585-Humans, pubmed-meshheading:21204585-Hydrophobic and Hydrophilic Interactions, pubmed-meshheading:21204585-Mice, pubmed-meshheading:21204585-Micelles, pubmed-meshheading:21204585-Nanoparticles, pubmed-meshheading:21204585-Neoplasms, pubmed-meshheading:21204585-Paclitaxel, pubmed-meshheading:21204585-Polymers, pubmed-meshheading:21204585-Protein-Serine-Threonine Kinases, pubmed-meshheading:21204585-Proto-Oncogene Proteins, pubmed-meshheading:21204585-RNA, Small Interfering, pubmed-meshheading:21204585-Time Factors, pubmed-meshheading:21204585-Xenograft Model Antitumor Assays
pubmed:year
2011
pubmed:articleTitle
Simultaneous delivery of siRNA and paclitaxel via a "two-in-one" micelleplex promotes synergistic tumor suppression.
pubmed:affiliation
Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, P.R. China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't