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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-3-29
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pubmed:abstractText |
Genetic variation of inosine triphosphatase (ITPA) causing an accumulation of inosine triphosphate (ITP) has been shown to protect patients against ribavirin (RBV)-induced anemia during treatment for chronic hepatitis C infection by genome-wide association study (GWAS). However, the biologic mechanism by which this occurs is unknown.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1528-0012
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
140
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1314-21
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pubmed:meshHeading |
pubmed-meshheading:21199653-Adenosine Triphosphate,
pubmed-meshheading:21199653-Adenylosuccinate Synthase,
pubmed-meshheading:21199653-Adolescent,
pubmed-meshheading:21199653-Adult,
pubmed-meshheading:21199653-Anemia,
pubmed-meshheading:21199653-Antiviral Agents,
pubmed-meshheading:21199653-Enzyme Activation,
pubmed-meshheading:21199653-Erythrocytes,
pubmed-meshheading:21199653-Genetic Variation,
pubmed-meshheading:21199653-Genotype,
pubmed-meshheading:21199653-Guanosine Triphosphate,
pubmed-meshheading:21199653-Hepatitis C, Chronic,
pubmed-meshheading:21199653-Humans,
pubmed-meshheading:21199653-Inosine Triphosphate,
pubmed-meshheading:21199653-Pyrophosphatases,
pubmed-meshheading:21199653-Ribavirin,
pubmed-meshheading:21199653-Young Adult
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pubmed:year |
2011
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pubmed:articleTitle |
Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by adenylosuccinate synthase function.
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pubmed:affiliation |
Center for Human Genome Variation, School of Medicine, Duke University, Durham, North Carolina, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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