Source:http://linkedlifedata.com/resource/pubmed/id/21193524
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2011-3-2
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| pubmed:abstractText |
Irritable bowel syndrome is characterized by colorectal hypersensitivity and contributed to by sensitized mechanosensitive primary afferents and recruitment of mechanoinsensitive (silent) afferents. Neurotrophic factors are well known to orchestrate dynamic changes in the properties of sensory neurons. Although pain modulation by proteins in the glial cell line-derived neurotrophic factor (GDNF) family has been documented in various pathophysiological states, their role in colorectal hypersensitivity remains unexplored. Therefore, we investigated the involvement of the GDNF family receptor ?-3 (GFR?3) signaling in visceral hypersensitivity by quantifying visceromotor responses (VMR) to colorectal distension before and after intracolonic treatment with 2,4,6-trinitrobenzene sulfonic acid (TNBS). Baseline responses to colorectal distension did not differ between C57BL/6 and GFR?3 knockout (KO) mice. Relative to intracolonic saline treatment, TNBS significantly enhanced the VMR to colorectal distension in C57BL/6 mice 2, 7, 10, and 14 days posttreatment, whereas TNBS-induced visceral hypersensitivity was significantly suppressed in GFR?3 KO mice. The proportion of GFR?3 immunopositive thoracolumbar and lumbosacral colorectal dorsal root ganglion neurons was significantly elevated 2 days after TNBS treatment. In single fiber recordings, responses to circumferential stretch of colorectal afferent endings in C57BL/6 mice were significantly increased (sensitized) after exposure to an inflammatory soup, whereas responses to stretch did not sensitize in GFR?3 KO mice. These findings suggest that enhanced GFR?3 signaling in visceral afferents may contribute to development of colorectal hypersensitivity.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Artn protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Gfra3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Glial Cell Line-Derived...,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trinitrobenzenesulfonic Acid
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
1522-1547
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
300
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
G418-24
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| pubmed:meshHeading |
pubmed-meshheading:21193524-Animals,
pubmed-meshheading:21193524-Colitis,
pubmed-meshheading:21193524-Colon,
pubmed-meshheading:21193524-Disease Models, Animal,
pubmed-meshheading:21193524-Electromyography,
pubmed-meshheading:21193524-Evoked Potentials,
pubmed-meshheading:21193524-Ganglia, Spinal,
pubmed-meshheading:21193524-Glial Cell Line-Derived Neurotrophic Factor Receptors,
pubmed-meshheading:21193524-Hyperalgesia,
pubmed-meshheading:21193524-Mechanotransduction, Cellular,
pubmed-meshheading:21193524-Mice,
pubmed-meshheading:21193524-Mice, Inbred C57BL,
pubmed-meshheading:21193524-Mice, Knockout,
pubmed-meshheading:21193524-Nerve Tissue Proteins,
pubmed-meshheading:21193524-Neurons, Afferent,
pubmed-meshheading:21193524-Pressure,
pubmed-meshheading:21193524-Rectum,
pubmed-meshheading:21193524-Time Factors,
pubmed-meshheading:21193524-Trinitrobenzenesulfonic Acid
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| pubmed:year |
2011
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| pubmed:articleTitle |
Modulation of visceral hypersensitivity by glial cell line-derived neurotrophic factor family receptor α-3 in colorectal afferents.
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| pubmed:affiliation |
Center for Pain Research, Departments of Anesthesiology, University of Pittsburgh, Pennsylvania, USA. Tanaka_Takahiro1@takeda.co.jp
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| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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