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21190850
Source:
http://linkedlifedata.com/resource/pubmed/id/21190850
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Statements in which the resource exists as a subject.
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Object
rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0015219
,
umls-concept:C0072899
,
umls-concept:C0205314
,
umls-concept:C0205549
,
umls-concept:C0678594
,
umls-concept:C0679622
,
umls-concept:C1446409
,
umls-concept:C1527178
,
umls-concept:C1705938
,
umls-concept:C1709060
pubmed:issue
2
pubmed:dateCreated
2011-1-11
pubmed:abstractText
Starting from compound 1, we utilized biostructural data to successfully evolve an existing series into a new chemotype with a promising overall profile, exemplified by 19.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Indans
,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles
,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, AMPA
,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1464-3405
pubmed:author
pubmed-author:BrownChristopher ICI
,
pubmed-author:CampbellRobert ARA
,
pubmed-author:GillenKevin JKJ
,
pubmed-author:GillespieJonathanJ
,
pubmed-author:JamiesonCraigC
,
pubmed-author:KazemierBertB
,
pubmed-author:KiczunMichaelM
,
pubmed-author:LamontYvonneY
,
pubmed-author:LyonsAmanda JAJ
,
pubmed-author:MacleanJohn K FJK
,
pubmed-author:MoirElizabeth MEM
,
pubmed-author:MorrowJohn AJA
,
pubmed-author:PantlingJohnJ
,
pubmed-author:RankovicZoranZ
,
pubmed-author:UlsoyHH
pubmed:copyrightInfo
Copyright © 2010 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
805-11
pubmed:meshHeading
pubmed-meshheading:21190850-Allosteric Regulation
,
pubmed-meshheading:21190850-Animals
,
pubmed-meshheading:21190850-Cell Line
,
pubmed-meshheading:21190850-Crystallography, X-Ray
,
pubmed-meshheading:21190850-Drug Design
,
pubmed-meshheading:21190850-Humans
,
pubmed-meshheading:21190850-Indans
,
pubmed-meshheading:21190850-Microsomes, Liver
,
pubmed-meshheading:21190850-Models, Molecular
,
pubmed-meshheading:21190850-Nervous System Diseases
,
pubmed-meshheading:21190850-Pyrazoles
,
pubmed-meshheading:21190850-Rats
,
pubmed-meshheading:21190850-Rats, Wistar
,
pubmed-meshheading:21190850-Receptors, AMPA
,
pubmed-meshheading:21190850-Structure-Activity Relationship
,
pubmed-meshheading:21190850-Sulfonamides
pubmed:year
2011
pubmed:articleTitle
Structure based evolution of a novel series of positive modulators of the AMPA receptor.
pubmed:affiliation
Merck Research Laboratories, MSD, Newhouse, Motherwell, Lanarkshire ML1 5SH, UK. craig.jamieson@strath.ac.uk
pubmed:publicationType
Journal Article