Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7339
pubmed:dateCreated
2011-3-24
pubmed:databankReference
pubmed:abstractText
Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and other key cellular processes. Here we present a genome-wide chromatin landscape for Drosophila melanogaster based on eighteen histone modifications, summarized by nine prevalent combinatorial patterns. Integrative analysis with other data (non-histone chromatin proteins, DNase I hypersensitivity, GRO-Seq reads produced by engaged polymerase, short/long RNA products) reveals discrete characteristics of chromosomes, genes, regulatory elements and other functional domains. We find that active genes display distinct chromatin signatures that are correlated with disparate gene lengths, exon patterns, regulatory functions and genomic contexts. We also demonstrate a diversity of signatures among Polycomb targets that include a subset with paused polymerase. This systematic profiling and integrative analysis of chromatin signatures provides insights into how genomic elements are regulated, and will serve as a resource for future experimental investigations of genome structure and function.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1476-4687
pubmed:author
pubmed-author:AlekseyenkoArtyom AAA, pubmed-author:BishopEric PEP, pubmed-author:CanfieldTheresa KTK, pubmed-author:ElginSarah C RSC, pubmed-author:ErnstJasonJ, pubmed-author:GorchakovAndrey AAA, pubmed-author:GuTingtingT, pubmed-author:JungYoungsook LYL, pubmed-author:KarpenGary HGH, pubmed-author:KellisManolisM, pubmed-author:KharchenkoPeter VPV, pubmed-author:KurodaMitzi IMI, pubmed-author:LarschanEricaE, pubmed-author:Linder-BassoDanielaD, pubmed-author:LuquetteLovelace JLJ, pubmed-author:MacAlpineDavid MDM, pubmed-author:MinodaAkiA, pubmed-author:ParkPeter JPJ, pubmed-author:ParkRichard WRW, pubmed-author:PirrottaVincenzoV, pubmed-author:PlachetkaAnnetteA, pubmed-author:RiddleNicole CNC, pubmed-author:SaboPeter JPJ, pubmed-author:SandstromRichardR, pubmed-author:SchwartzYuri BYB, pubmed-author:ShanowerGregoryG, pubmed-author:StamatoyannopoulosJohn AJA, pubmed-author:ThurmanRobert ERE, pubmed-author:TolstorukovMichael YMY, pubmed-author:XiRuibinR
pubmed:issnType
Electronic
pubmed:day
24
pubmed:volume
471
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
480-5
pubmed:dateRevised
2011-9-30
pubmed:meshHeading
pubmed-meshheading:21179089-Animals, pubmed-meshheading:21179089-Cell Line, pubmed-meshheading:21179089-Chromatin, pubmed-meshheading:21179089-Chromatin Immunoprecipitation, pubmed-meshheading:21179089-Chromosomal Proteins, Non-Histone, pubmed-meshheading:21179089-Deoxyribonuclease I, pubmed-meshheading:21179089-Drosophila Proteins, pubmed-meshheading:21179089-Drosophila melanogaster, pubmed-meshheading:21179089-Exons, pubmed-meshheading:21179089-Gene Expression Regulation, pubmed-meshheading:21179089-Genes, Insect, pubmed-meshheading:21179089-Genome, Insect, pubmed-meshheading:21179089-Histones, pubmed-meshheading:21179089-Male, pubmed-meshheading:21179089-Molecular Sequence Annotation, pubmed-meshheading:21179089-Oligonucleotide Array Sequence Analysis, pubmed-meshheading:21179089-RNA, pubmed-meshheading:21179089-Sequence Analysis, pubmed-meshheading:21179089-Transcription, Genetic
pubmed:year
2011
pubmed:articleTitle
Comprehensive analysis of the chromatin landscape in Drosophila melanogaster.
pubmed:affiliation
Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural