Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-9-14
pubmed:abstractText
Using 13C nuclear magnetic resonance spectroscopic methods we examined in vivo the synthesis of liver glycogen during the infusion of D-[1-13C]glucose and the turnover of labeled glycogen during subsequent infusion of D-[1-13C]glucose. In fasted rats the processes of glycogen synthesis and degradation were observed to occur simultaneously with the rate of synthesis much greater than degradation leading to net glycogen synthesis. In fed rats, incorporation of infused D-[1-13C]glucose occurred briskly; however, over 2 h there was no net glycogen accumulated. Degradation of labeled glycogen was greater in the fed versus the fasted rats (P less than 0.001), and the lack of net glycogen synthesis in fed rats was due to degradation and synthesis occurring at similar rates throughout the infusion period. There was no indication that suppression of phosphorylase a or subsequent activation of glycogen synthase was involved in modulation of the flux of tracer into liver glycogen. We conclude that in both fed and fasted rats, glycogen synthase and phosphorylase are active simultaneously and the levels of liver glycogen reached during refeeding are determined by the balance between ongoing synthetic and degradative processes.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-114169, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-183599, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-221294, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-2735403, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-3032540, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-3034711, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-3123491, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-3128534, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-3143265, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-3431407, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-3545824, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-3552523, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-3552525, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-3611353, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-3730768, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-4359036, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-4361283, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-4442420, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-4658986, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-5031114, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-5032528, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-5672839, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-5704765, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-6087672, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-6336701, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-6421171, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-6437238, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-6725277, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-6775172, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-6838841, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-6863277, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-7019243, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-7039339, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-75, http://linkedlifedata.com/resource/pubmed/commentcorrection/2117024-813634
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
86
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
612-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Simultaneous synthesis and degradation of rat liver glycogen. An in vivo nuclear magnetic resonance spectroscopic study.
pubmed:affiliation
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't