Linked Life Data

21166666

Source:http://linkedlifedata.com/resource/pubmed/id/21166666

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-1-6
pubmed:abstractText
Otitis media is one of the most common and intractable ear diseases, and is the major cause of hearing loss, especially in children. Multiple factors affect the onset or development of otitis media. Prostaglandin D? is the major prostanoid involved in infection and allergy. However, the role of prostaglandin D? and prostaglandin D2 receptors on the pathogenesis of otitis media remains to be determined. Recent studies show that D prostanoid receptor (DP) and chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) are major prostaglandin D? receptors. In this study, homozygous DP single gene-deficient (DP?(/)?) mice, CRTH2 single gene-deficient (CRTH2?(/)?) mice and DP/CRTH2 double gene-deficient (DP?(/)? CRTH2?(/)?) mice were used to investigate the role of prostaglandin D? and its receptors in otitis media. We demonstrate that prostaglandin D? is induced by lipopolysaccharide (LPS), a major component of Gram-negative bacteria, and that transtympanic injection of prostaglandin D? up-regulates macrophage inflammatory protein 2 (MIP-2), interleukin (IL)-1? and IL-6 in the middle ear. We also show that middle ear inflammatory reactions, including infiltration of inflammatory cells and expression of MIP-2, IL-1? and IL-6 induced by LPS, are reduced significantly in DP?(/)? mice and DP?(/)? CRTH2?(/)? mice. CRTH2?(/)? mice display inflammatory reactions similar to wild-type mice. These findings indicate that prostaglandin D? may play significant roles in LPS-induced experimental otitis media via DP.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1365-2249
pubmed:author
pubmed:copyrightInfo
© 2010 The Authors. Clinical and Experimental Immunology © 2010 British Society for Immunology.
pubmed:issnType
Electronic
pubmed:volume
163
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
260-9
pubmed:dateRevised
2011-3-3
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Lipopolysaccharide induces proinflammatory cytokines and chemokines in experimental otitis media through the prostaglandin D2 receptor (DP)-dependent pathway.
pubmed:affiliation
Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't