Linked Life Data

21164791

Source:http://linkedlifedata.com/resource/pubmed/id/21164791

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
24
pubmed:dateCreated
2010-12-17
pubmed:abstractText
Optical molecular imaging resulting from Cerenkov radiation has become a motivating topic recently and will potentially open new avenues for the study of small animal imaging. Cerenkov-based optical imaging taken from living animals in vivo has been studied with two-dimensional (2D) planar geometry and three-dimensional (3D) homogeneous mouse model. In this study, we performed 3D Cerenkov-based luminescence tomography (CLT) using a heterogeneous mouse model with an implanted Na(131)I radioactive source, which provided the accurate location for the reconstructed source. Furthermore, single photon emission computed tomography (SPECT) was utilized to verify the results of 3D CLT. We reconstructed the localization and intensity of an embedded radioactive source with various concentrations, and established a quantitative relationship between the radiotracer activity and the reconstructed intensity. The results showed the ability of in vivo CLT to recover the radioactive probe distribution in the heterogeneous mouse model and the potential of a SPECT imaging validation strategy to verify the results of optical molecular tomography.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1094-4087
pubmed:author
pubmed:issnType
Electronic
pubmed:day
22
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
24441-50
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Experimental Cerenkov luminescence tomography of the mouse model with SPECT imaging validation.
pubmed:affiliation
Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi’an, 710071, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Validation Studies