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pubmed-article:21163358pubmed:abstractTextTo evaluate aggrecanase activity after traumatic knee injury in a rat model by measuring the level of aggrecanase-generated Ala-Arg-Gly-aggrecan (ARG-aggrecan) fragments in synovial fluid, and compare with ARG-aggrecan release into joint fluid following human knee injury. To evaluate the effect of small molecule inhibitors on induced aggrecanase activity in the rat model.lld:pubmed
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pubmed-article:21163358pubmed:copyrightInfoCopyright © 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.lld:pubmed
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pubmed-article:21163358pubmed:articleTitleElevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor.lld:pubmed
pubmed-article:21163358pubmed:affiliationTissue Repair, BioTherapeutics Research & Development, Pfizer, Cambridge, MA 02140, USA. priya.chockalingam@pfizer.comlld:pubmed
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