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rdf:type |
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lifeskim:mentions |
umls-concept:C0022417,
umls-concept:C0026336,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0175677,
umls-concept:C0205250,
umls-concept:C0205369,
umls-concept:C0247689,
umls-concept:C0332161,
umls-concept:C0441655,
umls-concept:C1999216
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pubmed:issue |
3
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pubmed:dateCreated |
2011-2-28
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pubmed:abstractText |
To evaluate aggrecanase activity after traumatic knee injury in a rat model by measuring the level of aggrecanase-generated Ala-Arg-Gly-aggrecan (ARG-aggrecan) fragments in synovial fluid, and compare with ARG-aggrecan release into joint fluid following human knee injury. To evaluate the effect of small molecule inhibitors on induced aggrecanase activity in the rat model.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1522-9653
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pubmed:author |
pubmed-author:ChockalingamP SPS,
pubmed-author:DufieldD RDR,
pubmed-author:FlanneryC RCR,
pubmed-author:GeorgiadisK EKE,
pubmed-author:GlassonS SSS,
pubmed-author:LarssonSS,
pubmed-author:LohmanderL SLS,
pubmed-author:MorrisE AEA,
pubmed-author:Rivera-BermudezM AMA,
pubmed-author:SumPP,
pubmed-author:ZengWW
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pubmed:copyrightInfo |
Copyright © 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
315-23
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pubmed:meshHeading |
pubmed-meshheading:21163358-Aggrecans,
pubmed-meshheading:21163358-Animals,
pubmed-meshheading:21163358-Biological Markers,
pubmed-meshheading:21163358-Disease Models, Animal,
pubmed-meshheading:21163358-Endopeptidases,
pubmed-meshheading:21163358-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:21163358-Humans,
pubmed-meshheading:21163358-Knee Injuries,
pubmed-meshheading:21163358-Rats,
pubmed-meshheading:21163358-Rats, Inbred Lew,
pubmed-meshheading:21163358-Synovial Fluid
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pubmed:year |
2011
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pubmed:articleTitle |
Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor.
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pubmed:affiliation |
Tissue Repair, BioTherapeutics Research & Development, Pfizer, Cambridge, MA 02140, USA. priya.chockalingam@pfizer.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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