Linked Life Data

21162001

Source:http://linkedlifedata.com/resource/pubmed/id/21162001

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2010-12-16
pubmed:abstractText
Six new 6,7-seco-ent-kaurane diterpenoids, sculponeatins N-S (1-6, resp.), together with eleven known analogues, 7-17, were isolated from the aerial parts of Isodon sculponeatus. The structures of compounds 1-6 were elucidated by spectroscopic methods including extensive 1D- and 2D-NMR experiments, as well as HR-ESI-MS analysis. All diterpenoids obtained were assayed for their cytotoxic activity against K562 and HepG2 human tumor cell lines. Among them, compound 1 showed the most significant cytotoxicity with the IC?? values of 0.21 and 0.29??M, respectively. The structure-activity relationships are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1612-1880
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2888-96
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
6,7-seco-ent-kaurane diterpenoids from Isodon sculponeatus with cytotoxic activity.
pubmed:affiliation
Kunming Institute of Botany, Chinese Academy of Sciences, P?R China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't